Cancer Biology Select

Signal transduction pathways commonly go awry in cancer. Recent advances in understanding how these pathways contribute to tumor formation are the focus of this issue's Cancer Biology Select. New studies use RNAi-based screens and powerful mouse models to pull out critical factors essential for the survival of lung cancer cells. Other discoveries include a chemical-genomics approach to screen for drug efficacy, surprising crosstalk between two previously unconnected signaling pathways, and important implications for mobilization of tumor cells during metastasis