AbstractThe protein GM, which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasmic reticulum (SR) of striated muscles, is known to be phosphorylated at Ser48 and Ser67 in vitro by adenosine 3′,5′ cyclic monophosphate-dependent protein kinase (PKA) and at Ser48 by MAP kinase-activated protein kinase-1 (MAPKAP-K1, also called p90 RSK). The phosphorylation of Ser48 increases the rate at which the glycogen-associated PP1.GM complex dephosphorylates (activates) glycogen synthase, but the phosphorylation of Ser67 has the opposite effect, suppressing the activity of PP1 toward glycogen-bound substrates. The phosphorylation of Ser67 overrides the activating effect of Ser48 phosphorylation because it dissociates PP1 from GM...
Although the scheme hormone → raised cyclic AMP levels → activated protein kinase → phosphorylated p...
Multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr protein kinase unif...
The specificity of the catalytic subunit of protein phosphatase-1 (PP1(C)) is modified by regulatory...
AbstractThe protein GM, which targets protein phosphatase 1 (PP1) to the glycogen particles and sarc...
The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasm...
Adrenaline and insulin are the major hormones regulating glycogen metabolism in skeletal muscle. We ...
Multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr protein kinase unif...
AbstractThe in vivo phosphorylation stoichiometries of 4 serines on the glycogen-binding (G)-subunit...
AbstractThe glycogen-binding (G) subunit of protein phosphatase-1 is phosphorylated in vivo. In rabb...
AbstractThe glycogen-binding (G) subunit of protein phosphatase-1G is phosphorylated stoichiometrica...
SummaryGlycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric st...
The in vivo phosphorylation stoichiometries of 4 serines on the glycogen-binding (G)-subunit of prot...
We investigated the subcellular localization of glycogen synthase (GS) in the adductor muscle of ane...
AbstractA full-length cDNA encoding the putative hepatic glycogen-binding (GL) subunit of protein ph...
In mammals, excess carbohydrate is stored as glycogen and glycogen synthase is the enzyme that incor...
Although the scheme hormone → raised cyclic AMP levels → activated protein kinase → phosphorylated p...
Multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr protein kinase unif...
The specificity of the catalytic subunit of protein phosphatase-1 (PP1(C)) is modified by regulatory...
AbstractThe protein GM, which targets protein phosphatase 1 (PP1) to the glycogen particles and sarc...
The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasm...
Adrenaline and insulin are the major hormones regulating glycogen metabolism in skeletal muscle. We ...
Multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr protein kinase unif...
AbstractThe in vivo phosphorylation stoichiometries of 4 serines on the glycogen-binding (G)-subunit...
AbstractThe glycogen-binding (G) subunit of protein phosphatase-1 is phosphorylated in vivo. In rabb...
AbstractThe glycogen-binding (G) subunit of protein phosphatase-1G is phosphorylated stoichiometrica...
SummaryGlycogen synthase (GS), a key enzyme in glycogen synthesis, is activated by the allosteric st...
The in vivo phosphorylation stoichiometries of 4 serines on the glycogen-binding (G)-subunit of prot...
We investigated the subcellular localization of glycogen synthase (GS) in the adductor muscle of ane...
AbstractA full-length cDNA encoding the putative hepatic glycogen-binding (GL) subunit of protein ph...
In mammals, excess carbohydrate is stored as glycogen and glycogen synthase is the enzyme that incor...
Although the scheme hormone → raised cyclic AMP levels → activated protein kinase → phosphorylated p...
Multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaMKII) is a Ser/Thr protein kinase unif...
The specificity of the catalytic subunit of protein phosphatase-1 (PP1(C)) is modified by regulatory...