In this issue of Structure, Bunney and colleagues use a combination of NMR, SAXS, crystallography, ITC, and biochemical methods to elucidate, in molecular detail, the sequence of events causing receptor-mediated activation of phospholipase C-γ1 by protein tyrosine phosphorylation
The phospholipase C (PLC)-γ isozymes (-γ1 and -γ2) are activated by phosphorylation downstream of nu...
BACKGROUND: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare va...
G-protein-coupled receptors are cell surface macromolecules that regulate numerous cell physiologies...
In this issue of Structure, Bunney and colleagues use a combination of NMR, SAXS, crystallography, I...
Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPa...
The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and ...
Phospholipase C (PLC) isozymes regulate numerous cellular events including fertilization, proliferat...
SummaryPhospholipase C β (PLCβ) enzymes are dramatically activated by heterotrimeric G proteins. Cen...
Graduation date: 2008Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled\ud si...
Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second messenge...
DoctorPhospholipase C (PLC) is a key enzyme in signal transduction by catalyzing the formation of in...
AbstractPhospholipase Cβ2 (PLCβ2) is a large, multidomain enzyme that catalyzes the hydrolysis of th...
Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes ...
All peripheral membrane proteins must negotiate unique constraints intrinsic to the biological inter...
Phospholipase C enzymes are a class of enzymes that catalyse the cleavage of the membrane phospholi...
The phospholipase C (PLC)-γ isozymes (-γ1 and -γ2) are activated by phosphorylation downstream of nu...
BACKGROUND: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare va...
G-protein-coupled receptors are cell surface macromolecules that regulate numerous cell physiologies...
In this issue of Structure, Bunney and colleagues use a combination of NMR, SAXS, crystallography, I...
Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPa...
The lipase activity of most phospholipases C (PLCs) is basally repressed by a highly degenerate and ...
Phospholipase C (PLC) isozymes regulate numerous cellular events including fertilization, proliferat...
SummaryPhospholipase C β (PLCβ) enzymes are dramatically activated by heterotrimeric G proteins. Cen...
Graduation date: 2008Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled\ud si...
Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second messenge...
DoctorPhospholipase C (PLC) is a key enzyme in signal transduction by catalyzing the formation of in...
AbstractPhospholipase Cβ2 (PLCβ2) is a large, multidomain enzyme that catalyzes the hydrolysis of th...
Numerous receptor tyrosine kinases and immune receptors activate phospholipase C-γ (PLC-γ) isozymes ...
All peripheral membrane proteins must negotiate unique constraints intrinsic to the biological inter...
Phospholipase C enzymes are a class of enzymes that catalyse the cleavage of the membrane phospholi...
The phospholipase C (PLC)-γ isozymes (-γ1 and -γ2) are activated by phosphorylation downstream of nu...
BACKGROUND: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare va...
G-protein-coupled receptors are cell surface macromolecules that regulate numerous cell physiologies...
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