AbstractTranscriptional regulation and membrane traffic have traditionally been quite separate fields of biology, but they have been brought under the same roof by recent advances in understanding the cellular control of cholesterol metabolism
Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesi...
AbstractThrough expression cloning we have isolated a cDNA-encoding SREBP cleavage–activating protei...
Cholesterol is a vital lipid that performs diverse functions on a whole body and cellular level. Dis...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...
AbstractThree new studies have wide implications for cholesterol homeostasis, identifying a novel me...
ate cholesterol synthesis and uptake. This system maintains cholesterol homeostasis by increasing ch...
SummaryAnimal cells control their membrane lipid composition within narrow limits, but the sensing m...
SummaryThis paper describes a convergent mechanism for the feedback control of cholesterol synthesis...
AbstractCholesterol homeostasis in animal cells is achieved by regulated cleavage of membrane-bound ...
AbstractCholesterol homeostasis is established by a complex of three proteins, one of which contains...
Presents Cholesterol homeostasis in mammalian cells is regulated at the level of transcription throu...
The regulatory pool of cholesterol is located in the endoplasmic reticulum (ER) and is key to how ma...
SREBP complex is incorporated into COPII-coated vesicles that bud from the ER and carry the SREBPs t...
The maintenance of intracellular cholesterol homeostasis relies on a fascinating interplay between m...
SummaryElevated plasma cholesterol levels are considered responsible for excess cardiovascular morbi...
Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesi...
AbstractThrough expression cloning we have isolated a cDNA-encoding SREBP cleavage–activating protei...
Cholesterol is a vital lipid that performs diverse functions on a whole body and cellular level. Dis...
AbstractSREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has sh...
AbstractThree new studies have wide implications for cholesterol homeostasis, identifying a novel me...
ate cholesterol synthesis and uptake. This system maintains cholesterol homeostasis by increasing ch...
SummaryAnimal cells control their membrane lipid composition within narrow limits, but the sensing m...
SummaryThis paper describes a convergent mechanism for the feedback control of cholesterol synthesis...
AbstractCholesterol homeostasis in animal cells is achieved by regulated cleavage of membrane-bound ...
AbstractCholesterol homeostasis is established by a complex of three proteins, one of which contains...
Presents Cholesterol homeostasis in mammalian cells is regulated at the level of transcription throu...
The regulatory pool of cholesterol is located in the endoplasmic reticulum (ER) and is key to how ma...
SREBP complex is incorporated into COPII-coated vesicles that bud from the ER and carry the SREBPs t...
The maintenance of intracellular cholesterol homeostasis relies on a fascinating interplay between m...
SummaryElevated plasma cholesterol levels are considered responsible for excess cardiovascular morbi...
Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesi...
AbstractThrough expression cloning we have isolated a cDNA-encoding SREBP cleavage–activating protei...
Cholesterol is a vital lipid that performs diverse functions on a whole body and cellular level. Dis...
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