AbstractLymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-κB induction and JNK activation
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
Natural (n) T regulatory (Treg) cells generated in the thymus are essential throughout life for the ...
T cells are critical players in adaptive immunity. They migrate throughout the body scanning the ly...
Antigen receptor-induced NF-κB activation depends on receptor-proximal and -distal signaling events....
AbstractIn a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was i...
Ligation of antigen receptors (TCR, BCR) on T and B lymphocytes leads to the activation of new trans...
AbstractCARMA1 (originally called CARD11) is a membrane-associated guanylate kinase family member th...
In a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was isolated ...
CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of...
AbstractMembers of the MAGUK family proteins cluster receptors and intracellular signaling molecules...
SummaryCARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CAR...
Abstract : Activation of naïve T lymphocytes is essential for the onset of an adaptive immune respon...
Antigen receptor-induced NF-kappaB activation depends on receptor-proximal and -distal signaling eve...
SummaryPKC isoforms and CARMA1 play crucial roles in immunoreceptor-dependent NF-κB activation. We t...
The CARMA1-BCL10-MALT1 (CBM) signalosome triggers canonical NF-κB signaling and lymphocyte act...
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
Natural (n) T regulatory (Treg) cells generated in the thymus are essential throughout life for the ...
T cells are critical players in adaptive immunity. They migrate throughout the body scanning the ly...
Antigen receptor-induced NF-κB activation depends on receptor-proximal and -distal signaling events....
AbstractIn a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was i...
Ligation of antigen receptors (TCR, BCR) on T and B lymphocytes leads to the activation of new trans...
AbstractCARMA1 (originally called CARD11) is a membrane-associated guanylate kinase family member th...
In a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was isolated ...
CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of...
AbstractMembers of the MAGUK family proteins cluster receptors and intracellular signaling molecules...
SummaryCARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CAR...
Abstract : Activation of naïve T lymphocytes is essential for the onset of an adaptive immune respon...
Antigen receptor-induced NF-kappaB activation depends on receptor-proximal and -distal signaling eve...
SummaryPKC isoforms and CARMA1 play crucial roles in immunoreceptor-dependent NF-κB activation. We t...
The CARMA1-BCL10-MALT1 (CBM) signalosome triggers canonical NF-κB signaling and lymphocyte act...
CARMA proteins are scaffold molecules that contain a caspase recruitment domain and a membrane-assoc...
Natural (n) T regulatory (Treg) cells generated in the thymus are essential throughout life for the ...
T cells are critical players in adaptive immunity. They migrate throughout the body scanning the ly...
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