The ability to distinguish self from nonself is crucial for proper immune system function, and disruption of self-tolerance can lead to the development of autoimmune disease. This Immunology Select highlights recent studies that uncover new mechanisms for inducing self-tolerance and provides insights into how self-tolerance breaks down in disease
A pool of immature T cells with a seemingly unrestricted repertoire of antigen specificities is gene...
© 2012 Dr. Ellen Margaret RossIn order to protect the host from disease, the immune system is equipp...
SummaryAire promotes the tolerization of thymocytes by inducing the expression of a battery of perip...
The ability to distinguish self from nonself is crucial for proper immune system function, and disru...
peer reviewedBefore reacting against non-self infectious agents, the immune system is educated to t...
SummaryThe degree of T cell self-reactivity considered dangerous by the immune system, thereby requi...
Rearrangement of the antigen-specific lymphocyte receptor genes generates repertoire of T and B cell...
The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recent...
© 2015 Dr. Sarah Anne OverallThe recognition of self-antigen by the T cell receptor (TCR) defines T ...
The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recent...
AbstractThe immunodominant epitope of myelin basic protein, Ac1–9, is encephalitogenic in H-2u mice....
Deletion of self-antigen-specific T cells during thymic development provides protection from autoimm...
SummaryDeletion of self-antigen-specific T cells during thymic development provides protection from ...
Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible...
A pool of immature T cells with a seemingly unrestricted repertoire of antigen specificities is gene...
A pool of immature T cells with a seemingly unrestricted repertoire of antigen specificities is gene...
© 2012 Dr. Ellen Margaret RossIn order to protect the host from disease, the immune system is equipp...
SummaryAire promotes the tolerization of thymocytes by inducing the expression of a battery of perip...
The ability to distinguish self from nonself is crucial for proper immune system function, and disru...
peer reviewedBefore reacting against non-self infectious agents, the immune system is educated to t...
SummaryThe degree of T cell self-reactivity considered dangerous by the immune system, thereby requi...
Rearrangement of the antigen-specific lymphocyte receptor genes generates repertoire of T and B cell...
The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recent...
© 2015 Dr. Sarah Anne OverallThe recognition of self-antigen by the T cell receptor (TCR) defines T ...
The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recent...
AbstractThe immunodominant epitope of myelin basic protein, Ac1–9, is encephalitogenic in H-2u mice....
Deletion of self-antigen-specific T cells during thymic development provides protection from autoimm...
SummaryDeletion of self-antigen-specific T cells during thymic development provides protection from ...
Regulatory mechanisms are necessary to avoid the misdirected aggressive immune responses responsible...
A pool of immature T cells with a seemingly unrestricted repertoire of antigen specificities is gene...
A pool of immature T cells with a seemingly unrestricted repertoire of antigen specificities is gene...
© 2012 Dr. Ellen Margaret RossIn order to protect the host from disease, the immune system is equipp...
SummaryAire promotes the tolerization of thymocytes by inducing the expression of a battery of perip...