SummaryHippocampal activity influences neurogenesis in the adult dentate gyrus; however, little is known about the involvement of the hippocampal circuitry in this process. In the subgranular zone of the adult dentate gyrus, neurogenesis involves a series of differentiation steps from radial glia-like stem/progenitor (type-1) cells, to transiently amplifying neuronal progenitor (type-2) cells, to postmitotic neurons. In this study, we conducted GFP-targeted recordings of progenitor cells in fresh hippocampal slices from nestin-GFP mice and found that neuronal progenitor (type-2) cells receive active direct neural inputs from the hippocampal circuitry. This input was GABAergic but not glutamatergic. The GABAergic inputs depolarized type-2 ce...
The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the pr...
Fate choice decision and the initiation of neuronal development occur in precursor cells of the adul...
Neurogenesis in the dentate gyrus of the hippocampus follows a unique temporal pattern that begins d...
SummaryHippocampal activity influences neurogenesis in the adult dentate gyrus; however, little is k...
The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in ...
AbstractA wide variety of in vivo manipulations influence neurogenesis in the adult hippocampus. It ...
Although neural progenitor cells (NPCs) may provide a source of new neurons to alleviate neural trau...
The dentate gyrus of the hippocampus contains neural progenitor cells (NPCs) that generate neurons t...
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we show that prolife...
In the mature dentate gyrus (DG) new neurons are continuously produced in a process known as adult n...
In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural st...
Stem cells have the extraordinary potential to produce many different cell types. The hippocampus is...
In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural st...
Cell proliferation and differentiation are interdependent processes. Here, we have asked to what ext...
Throughout the adult life of all mammals including humans, new neurons are incorporated to the denta...
The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the pr...
Fate choice decision and the initiation of neuronal development occur in precursor cells of the adul...
Neurogenesis in the dentate gyrus of the hippocampus follows a unique temporal pattern that begins d...
SummaryHippocampal activity influences neurogenesis in the adult dentate gyrus; however, little is k...
The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in ...
AbstractA wide variety of in vivo manipulations influence neurogenesis in the adult hippocampus. It ...
Although neural progenitor cells (NPCs) may provide a source of new neurons to alleviate neural trau...
The dentate gyrus of the hippocampus contains neural progenitor cells (NPCs) that generate neurons t...
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we show that prolife...
In the mature dentate gyrus (DG) new neurons are continuously produced in a process known as adult n...
In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural st...
Stem cells have the extraordinary potential to produce many different cell types. The hippocampus is...
In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural st...
Cell proliferation and differentiation are interdependent processes. Here, we have asked to what ext...
Throughout the adult life of all mammals including humans, new neurons are incorporated to the denta...
The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the pr...
Fate choice decision and the initiation of neuronal development occur in precursor cells of the adul...
Neurogenesis in the dentate gyrus of the hippocampus follows a unique temporal pattern that begins d...