Hypercholesterolemia is a major cause of cardiovascular disease and can be treated by targeting bile acid and cholesterol metabolism. Vergnes et al. (2013) now identify Diet1 as a novel regulator of fibroblast growth factor 15/19 production and bile acid biosynthesis
Hepatic bile acid synthesis is subject to complex modes of transcriptional control, in which the bil...
International audienceBackground and aims: Hypercholesterolemia is a major risk factor for atheroscl...
The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to glycine or...
Elevated cholesterol levels are associated with increased risk for atherosclerosis, heart disease an...
Fibroblast growth factor 15 (Fgf15), a hormone made by the terminal ileum in response to bile acids,...
Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea...
AbstractThe classical functions of bile acids include acting as detergents to facilitate the digesti...
Bile acid metabolism plays an essential role in cholesterol homeostasis and is critical for the init...
SummaryThe liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we dem...
Cholesterol is essential for normal growth and development in mammals. However, excess cholesterol c...
BACKGROUND & AIMS: Cholestasis is a liver disorder characterized by impaired bile flow, reduction ...
SummaryWe identified a mutation in the Diet1 gene in a mouse strain that is resistant to hyperlipide...
Cholangiocytes, bile duct lining cells, actively adjust the amount of cholesterol and bile acids in ...
SummaryBile acids are synthesized from cholesterol in the liver and further metabolized by the gut m...
Hepatic bile acid synthesis is subject to complex modes of transcriptional control, in which the bil...
International audienceBackground and aims: Hypercholesterolemia is a major risk factor for atheroscl...
The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to glycine or...
Elevated cholesterol levels are associated with increased risk for atherosclerosis, heart disease an...
Fibroblast growth factor 15 (Fgf15), a hormone made by the terminal ileum in response to bile acids,...
Bile acid malabsorption, which in patients leads to excessive fecal bile acid excretion and diarrhea...
AbstractThe classical functions of bile acids include acting as detergents to facilitate the digesti...
Bile acid metabolism plays an essential role in cholesterol homeostasis and is critical for the init...
SummaryThe liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we dem...
Cholesterol is essential for normal growth and development in mammals. However, excess cholesterol c...
BACKGROUND & AIMS: Cholestasis is a liver disorder characterized by impaired bile flow, reduction ...
SummaryWe identified a mutation in the Diet1 gene in a mouse strain that is resistant to hyperlipide...
Cholangiocytes, bile duct lining cells, actively adjust the amount of cholesterol and bile acids in ...
SummaryBile acids are synthesized from cholesterol in the liver and further metabolized by the gut m...
Hepatic bile acid synthesis is subject to complex modes of transcriptional control, in which the bil...
International audienceBackground and aims: Hypercholesterolemia is a major risk factor for atheroscl...
The primary bile acids (BAs) are synthetized from cholesterol in the liver, conjugated to glycine or...
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