SummaryAdult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in the dentate gyrus (DG) that are capable of continuous proliferation and neuronal differentiation are the source of such structural plasticity. Here we report that mice lacking the receptor tyrosine kinase TrkB in hippocampal NPCs have impaired proliferation and neurogenesis. When exposed to chronic ADs or wheel-running, no increase in proliferation or neurogenesis is observed. Ablation of TrkB also renders these mice behaviorally insensitive to antidepressive treatment in depression- and anxiety-like paradigms. In contrast, mice lacking TrkB only in differentiated DG neurons disp...
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functiona...
It is widely accepted that changes underlying depression and antidepressant-like effects involve not...
Depression is characterized by atrophy in several brain structures, with the hippocampus seemingly p...
SummaryAdult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (AD...
Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adu...
Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-derived ...
Brain-derived neurotrophic factor (BDNF) exerts antidepressant-like effects in the hippocampus and p...
Growing evidence indicates that impairment of the stress response, in particular the negative feedba...
<p>Background: Depression and anxiety disorders have been linked to dysfunction of the hypotha...
The outbread Roman High- (RHA) and Roman Low-Avoidance (RLA) rat lines were psychogenetically select...
Various chronic antidepressant treatments increase adult hippocampal neurogen-esis, but the function...
Mood disorders are associated with deficits in hippocampal size and function. Neurogenesis in the de...
Previous studies suggest that the responsiveness of TrkB receptor to BDNF is developmentally regulat...
Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like sy...
BACKGROUND: Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic ...
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functiona...
It is widely accepted that changes underlying depression and antidepressant-like effects involve not...
Depression is characterized by atrophy in several brain structures, with the hippocampus seemingly p...
SummaryAdult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (AD...
Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adu...
Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-derived ...
Brain-derived neurotrophic factor (BDNF) exerts antidepressant-like effects in the hippocampus and p...
Growing evidence indicates that impairment of the stress response, in particular the negative feedba...
<p>Background: Depression and anxiety disorders have been linked to dysfunction of the hypotha...
The outbread Roman High- (RHA) and Roman Low-Avoidance (RLA) rat lines were psychogenetically select...
Various chronic antidepressant treatments increase adult hippocampal neurogen-esis, but the function...
Mood disorders are associated with deficits in hippocampal size and function. Neurogenesis in the de...
Previous studies suggest that the responsiveness of TrkB receptor to BDNF is developmentally regulat...
Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like sy...
BACKGROUND: Antidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic ...
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functiona...
It is widely accepted that changes underlying depression and antidepressant-like effects involve not...
Depression is characterized by atrophy in several brain structures, with the hippocampus seemingly p...