Epigenetic Memory Meets G2/M: To Remember or To Forget?
- Sharif, Jafar
- Endoh, Mitsuhiro
- Koseki, Haruhiko
Publication date
January 2011
DOI Publisher
Elsevier Inc. ISSN
1534-5807 Citation count (estimate)
5Abstract
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation. Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase
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