AbstractWe have previously reported that cyclothiazide (CTZ) evokes epileptiform activities in hippocampal neurons and induces seizure behavior. Here we further studied in vivo the sensitivity of the hippocampal CA1 neurons in response to CTZ in epileptogenesis in comparison with two other classic convulsants of kainic acid (KA) and pentylenetetrazol (PTZ).CTZ administered intracerebral ventricle (i.c.v.) induced epileptiform activities from an initial of multiple evoked population spikes, progressed to spontaneous spikes and finally to highly synchronized burst activities in hippocampal CA1 neurons. PTZ, when given by subcutaneously, but not by intracerebral ventricle injection, evoked similar progressive epileptiform activities. In contra...
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotran...
Ganoderic acid A (GAA) exhibited neuron protection in in vitro epilepsy study, but no study has been...
Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular me...
AbstractWe have previously reported that cyclothiazide (CTZ) evokes epileptiform activities in hippo...
Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and in...
Medial temporal lobe epilepsy (mTLE) is one of the most common epilepsies in the human population, y...
Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain s...
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play an important function in neurona...
Experiments were carried out on hippocampal slices from control rats and those pretreated with a uni...
International audienceAstrocytes are integral functional components of synapses, regulating transmis...
The hippocampus plays a crucial role in seizure generation in temporal lobe epilepsy (TLE), a common...
SummaryThis study was aimed to quantitatively evaluate the effects of topiramate (TPM) on seizure su...
Objective. One third of epilepsy patients cannot be helped using conventional medication. Selective ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
AbstractInjection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus ...
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotran...
Ganoderic acid A (GAA) exhibited neuron protection in in vitro epilepsy study, but no study has been...
Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular me...
AbstractWe have previously reported that cyclothiazide (CTZ) evokes epileptiform activities in hippo...
Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and in...
Medial temporal lobe epilepsy (mTLE) is one of the most common epilepsies in the human population, y...
Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain s...
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB play an important function in neurona...
Experiments were carried out on hippocampal slices from control rats and those pretreated with a uni...
International audienceAstrocytes are integral functional components of synapses, regulating transmis...
The hippocampus plays a crucial role in seizure generation in temporal lobe epilepsy (TLE), a common...
SummaryThis study was aimed to quantitatively evaluate the effects of topiramate (TPM) on seizure su...
Objective. One third of epilepsy patients cannot be helped using conventional medication. Selective ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
AbstractInjection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus ...
Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotran...
Ganoderic acid A (GAA) exhibited neuron protection in in vitro epilepsy study, but no study has been...
Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular me...