Retromer Mediates a Discrete Route of Local Membrane Delivery to Dendrites
- Choy, Regina Wai-Yan
- Park, Minjong
- Temkin, Paul
- Herring, Bruce E.
- Marley, Aaron
- Nicoll, Roger A.
- von Zastrow, Mark
DOIAbstract
SummaryA fundamental and still largely unresolved question is how neurons achieve rapid delivery of selected signaling receptors throughout the elaborate dendritic arbor. Here we show that this requires a conserved sorting machinery called retromer. Retromer-associated endosomes are distributed within dendrites in ∼2 μm intervals and supply frequent membrane fusion events into the dendritic shaft domain immediately adjacent to (<300 nm from) the donor endosome and typically without full endosome discharge. Retromer-associated endosomes contain β-adrenergic receptors as well as ionotropic glutamate receptors, and retromer knockdown reduces extrasynaptic insertion of adrenergic receptors as well as functional expression of AMPA and NMDA recep...
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