AbstractCell death in B cell terminal differentiation rapidly follows cell cycle arrest in IL-6 differentiation of EBV-immortalized, IgG-bearing human lymphoblastoid cells in vitro. G1 arrest is now found to coincide with repression of EBNA2 and LMP1, two EBV genes essential for B cell transformation, without activation of the viral lytic cycle. IL-6–differentiated B cells die by apoptosis, as evidenced by increases in Annexin V binding activity, PARP cleavage, and chromatin disorganization. Expression of Mcl-1, a Bcl-2 family member, was specifically induced during IL-6 differentiation and down-regulated during apoptosis. Thus, IL-6 reverses EBV immortalization and activates the terminal differentiation program in IgG-bearing human B lymph...
SummaryEpstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects an...
peer reviewedBACKGROUND: EBV lytic cycle activators, such as phorbol esters, anti-immunoglobulin, tr...
DNA viruses such as herpesviruses are known to encode homologs of cellular antiapoptotic viral Bcl-2...
Cell cycle arrest and cell death are tightly coupled to terminal differentiation of B cells to plasm...
AbstractCell cycle arrest and cell death are tightly coupled to terminal differentiation of B cells ...
Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. I...
The genome of Epstein-Barr virus (EBV) encodes 86 proteins, but only a limited set is expressed in E...
Epstein-Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma (BL), an...
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in ...
Epstein-Barr virus (EBV) is associated with B-cell lymphomas such as Hodgkin lymphoma, Burkitt lymph...
Infection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and...
Epstein-Barr virus (EBV) infects human primary B lymphocytes and induces and maintains proliferation...
Epstein-Barr virus (EBV) efficiently immortalizes B cells in vitro leading to the establishment of l...
To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the v...
Epstein-Barr virus (EBC) is a herpes virus that has a tropism for human B lymphocytes and is frequen...
SummaryEpstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects an...
peer reviewedBACKGROUND: EBV lytic cycle activators, such as phorbol esters, anti-immunoglobulin, tr...
DNA viruses such as herpesviruses are known to encode homologs of cellular antiapoptotic viral Bcl-2...
Cell cycle arrest and cell death are tightly coupled to terminal differentiation of B cells to plasm...
AbstractCell cycle arrest and cell death are tightly coupled to terminal differentiation of B cells ...
Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. I...
The genome of Epstein-Barr virus (EBV) encodes 86 proteins, but only a limited set is expressed in E...
Epstein-Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma (BL), an...
Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in ...
Epstein-Barr virus (EBV) is associated with B-cell lymphomas such as Hodgkin lymphoma, Burkitt lymph...
Infection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and...
Epstein-Barr virus (EBV) infects human primary B lymphocytes and induces and maintains proliferation...
Epstein-Barr virus (EBV) efficiently immortalizes B cells in vitro leading to the establishment of l...
To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the v...
Epstein-Barr virus (EBC) is a herpes virus that has a tropism for human B lymphocytes and is frequen...
SummaryEpstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects an...
peer reviewedBACKGROUND: EBV lytic cycle activators, such as phorbol esters, anti-immunoglobulin, tr...
DNA viruses such as herpesviruses are known to encode homologs of cellular antiapoptotic viral Bcl-2...