Oncogenic signaling frequently results in unscheduled overexpression of cell cycle proteins and replicative stress. In this issue of Cancer Cell, Schvartzman et al. show that inactivation of p53 or pRb induces Mad2, and the overexpression of this mitotic checkpoint protein is a necessary event during oncogene-induced mitotic stress
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of...
SummaryWhat specific defects can cause chromosomal instability in cancer cells? Overexpression of th...
Objective Cell-cycle checkpoints guarantee movement through the cell cycle. Mitotic arrest deficien...
The mitotic checkpoint protein hsMad2 is required to arrest cells in mitosis when chromosomes are un...
The mitotic arrest deficient 2 (MAD2) is suggested to play a key role in a functional mitotic checkp...
Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor loss lead to chrom...
Aneuploidy is a hallmark of most human cancers, but whether it is a cause or a consequence of cellul...
SummaryMad2 is an essential component of the spindle checkpoint that blocks activation of Separase a...
The Spindle Assembly Checkpoint (SAC) is a cellular surveillance mechanism that functions to ensure ...
SummaryChromosome instability (CIN) is associated with poor survival and therapeutic outcome in a nu...
Stability and fidelity of cell cycle is cruicial for the maintenance of genome. There are checkpoint...
Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase and diss...
p53 regulates a number of genes through transcriptional activation and repression. p53-dependent mit...
Chromosome instability is a commonly observed feature in ovarian carcinoma. Mitotic checkpoint contr...
The Spindle Assembly Checkpoint (SAC) is a cellular surveillance mechanism that ensures faithful chr...
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of...
SummaryWhat specific defects can cause chromosomal instability in cancer cells? Overexpression of th...
Objective Cell-cycle checkpoints guarantee movement through the cell cycle. Mitotic arrest deficien...
The mitotic checkpoint protein hsMad2 is required to arrest cells in mitosis when chromosomes are un...
The mitotic arrest deficient 2 (MAD2) is suggested to play a key role in a functional mitotic checkp...
Multiple mechanisms have been proposed to explain how Rb and p53 tumor suppressor loss lead to chrom...
Aneuploidy is a hallmark of most human cancers, but whether it is a cause or a consequence of cellul...
SummaryMad2 is an essential component of the spindle checkpoint that blocks activation of Separase a...
The Spindle Assembly Checkpoint (SAC) is a cellular surveillance mechanism that functions to ensure ...
SummaryChromosome instability (CIN) is associated with poor survival and therapeutic outcome in a nu...
Stability and fidelity of cell cycle is cruicial for the maintenance of genome. There are checkpoint...
Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase and diss...
p53 regulates a number of genes through transcriptional activation and repression. p53-dependent mit...
Chromosome instability is a commonly observed feature in ovarian carcinoma. Mitotic checkpoint contr...
The Spindle Assembly Checkpoint (SAC) is a cellular surveillance mechanism that ensures faithful chr...
Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of...
SummaryWhat specific defects can cause chromosomal instability in cancer cells? Overexpression of th...
Objective Cell-cycle checkpoints guarantee movement through the cell cycle. Mitotic arrest deficien...
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