Collagen Turnover in Wound Repair––A Macrophage Connection
- Nissinen, Liisa M.
- Kähäri, Veli-Matti
Publication date
October 2015
DOI Publisher
The Society for Investigative Dermatology, Inc. ISSN
0022-202X Citation count (estimate)
7Abstract
In this issue, Rohani et al. (2015) report on the role of macrophage-derived stromelysin-2 (matrix metalloproteinase (MMP)-10) in promoting the turnover of extracellular matrix (ECM) during cutaneous wound repair. They provide evidence that MMP-10 specifically enhances collagenolytic activity of murine MMP-13 produced by M2-like macrophages. These results emphasize the important role of macrophage-derived MMP-10 in regulating tissue remodeling and scar formation during wound healing
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