Targeted therapies directed against cell cycle regulators have been difficult to translate into the clinic. In this issue of Cancer Cell, Choi et al. and Sawai et al. rekindle the therapeutic value of inhibiting specific cyclin-dependent kinase complexes by demonstrating their requirements in the maintenance of breast tumors and leukemias
The cell cycle is a highly conserved and ordered set of events, culminating in cell growth and divis...
Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activ...
Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of a normal stem cel...
Targeted therapies directed against cell cycle regulators have been difficult to translate into the ...
The cell cycle consists of a number of complex biochemical pathways that ensure that the start of a ...
AbstractG1 is the phase of the cell cycle wherein the cell is responsive to growth factor-dependent ...
The loss of ability in controlling cell cycle leads to aberrant cell growth and is a hallmark of can...
During the past decades, cancer research has expanded rapidly due to the relatively high incidence r...
Cyclin-dependent kinases (CDKs) drive cell cycle progression and control transcriptional pro-cesses....
Several families of protein kinases orchestrate the complex events that drive the cell cycle, and th...
Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their functi...
AbstractThe prevailing view of cdk2 as a critical regulator of cell cycle progression and optimal th...
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered ex...
Previous studies have demonstrated that mice lacking Cyclin D1 were refractory to mammary tumor deve...
SummaryD-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-c...
The cell cycle is a highly conserved and ordered set of events, culminating in cell growth and divis...
Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activ...
Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of a normal stem cel...
Targeted therapies directed against cell cycle regulators have been difficult to translate into the ...
The cell cycle consists of a number of complex biochemical pathways that ensure that the start of a ...
AbstractG1 is the phase of the cell cycle wherein the cell is responsive to growth factor-dependent ...
The loss of ability in controlling cell cycle leads to aberrant cell growth and is a hallmark of can...
During the past decades, cancer research has expanded rapidly due to the relatively high incidence r...
Cyclin-dependent kinases (CDKs) drive cell cycle progression and control transcriptional pro-cesses....
Several families of protein kinases orchestrate the complex events that drive the cell cycle, and th...
Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their functi...
AbstractThe prevailing view of cdk2 as a critical regulator of cell cycle progression and optimal th...
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered ex...
Previous studies have demonstrated that mice lacking Cyclin D1 were refractory to mammary tumor deve...
SummaryD-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-c...
The cell cycle is a highly conserved and ordered set of events, culminating in cell growth and divis...
Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activ...
Within a tumor, Cancer Stem Cells (CSCs) exists and own similar characteristics of a normal stem cel...
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