AbstractThe serine-threonine kinase gene AURORA-A is commonly amplified in epithelial malignancies. Here we show that elevated Aurora-A expression at levels that reflect cancer-associated gene amplification overrides the checkpoint mechanism that monitors mitotic spindle assembly, inducing resistance to the chemotherapeutic agent paclitaxel (Taxol). Cells overexpressing Aurora-A inappropriately enter anaphase despite defective spindle formation, and the persistence of Mad2 at the kinetochores, marking continued activation of the spindle assembly checkpoint. Mitosis is subsequently arrested by failure to complete cytokinesis, resulting in multinucleation. This abnormality is relieved by an inhibitory mutant of BUB1, linking the mitotic abnor...
Recently, new chemotherapy agents which target the non-structural components of mitosis have been de...
In mitosis, the kinetochores of chromosomes that lack full microtubule attachments and/or mechanical...
Abstract Background A large percentage of patients with recurrent ovarian cancer develop resistance ...
AbstractThe serine-threonine kinase gene AURORA-A is commonly amplified in epithelial malignancies. ...
International audienceThe amplification of AURORA-A is frequently observed in specific epithelial ce...
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was pre...
Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Auro...
International audienceDuring the prometaphase stage of mitosis, the cell builds a bipolar spindle of...
Aurora-A is a centrosome-associated serine/threonine kinase that is overexpressed in multiple types ...
Faithful separation of chromosomes prior to cell division at mitosis is a highly regulated process. ...
Protein kinases "Aurora " are the key regulators of the cell cycle. While the activity of Aurora-A i...
Recently, new chemotherapy agents which target the non-structural components of mitosis have been de...
AbstractWe investigated why treatment of cells with dual aurora A and B kinase inhibitors produces p...
2015-08-17Aurora A belongs to a family of serine/threonine kinases known to play a role in mitotic r...
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was pre...
Recently, new chemotherapy agents which target the non-structural components of mitosis have been de...
In mitosis, the kinetochores of chromosomes that lack full microtubule attachments and/or mechanical...
Abstract Background A large percentage of patients with recurrent ovarian cancer develop resistance ...
AbstractThe serine-threonine kinase gene AURORA-A is commonly amplified in epithelial malignancies. ...
International audienceThe amplification of AURORA-A is frequently observed in specific epithelial ce...
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was pre...
Aurora B kinase regulates the proper biorientation of sister chromatids during mitosis. Lack of Auro...
International audienceDuring the prometaphase stage of mitosis, the cell builds a bipolar spindle of...
Aurora-A is a centrosome-associated serine/threonine kinase that is overexpressed in multiple types ...
Faithful separation of chromosomes prior to cell division at mitosis is a highly regulated process. ...
Protein kinases "Aurora " are the key regulators of the cell cycle. While the activity of Aurora-A i...
Recently, new chemotherapy agents which target the non-structural components of mitosis have been de...
AbstractWe investigated why treatment of cells with dual aurora A and B kinase inhibitors produces p...
2015-08-17Aurora A belongs to a family of serine/threonine kinases known to play a role in mitotic r...
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was pre...
Recently, new chemotherapy agents which target the non-structural components of mitosis have been de...
In mitosis, the kinetochores of chromosomes that lack full microtubule attachments and/or mechanical...
Abstract Background A large percentage of patients with recurrent ovarian cancer develop resistance ...