AbstractDirect sequencing and reverse hybridization are currently the main methods for detecting drug-resistance mutations of hepatitis B virus (HBV). However, these methods do not enable haplotype analysis so they cannot be used to determine whether the mutations are co-located on the same viral genome. This limits the accurate identification of viral mutants that are resistant to drugs with a high genetic barrier. In our current study, ultra-deep pyrosequencing (UDPS) was used to detect HBV drug-resistance mutations in 25 entecavir-treated and five treatment-naive patients. Of the 25 entecavir-treated patients, 18 had experienced virological breakthrough and two exhibited reduced susceptibility to entecavir. The results obtained by UDPS w...
Resistance to anti-viral drugs is a global problem in the treatment of HBV. Around 350 million peopl...
Background: Hepatitis B Virus (HBV) infection is one of the major causes of liver cirrhosis, hepatoc...
TEZ10647Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2014.Kaynakça (s. 102-111) var.xii, 112...
AbstractDirect sequencing and reverse hybridization are currently the main methods for detecting dru...
Direct population sequencing and reverse hybridization (line probe assay [LiPA])-based methods are t...
The dynamics of emerging nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI) resistance...
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therap...
Although the advent of ultra-deep sequencing technology allows for the analysis of heretofore-undete...
Monitoring of drug resistance mutations in Hepatitis B virus (HBV) is critical for the management of...
BACKGROUND: Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog...
BACKGROUND AND AIMS: Although the advent of ultra-deep sequencing technology allows for the analysis...
WOS: 000463053800023Introduction: The development of drug resistance mutations to nucleos(t)ide anal...
International audienceHepatitis B virus (HBV) resistance to nucleoside/nucleotide analogs is frequen...
HBV DNA replicates through a genomic RNA intermediate. The HBV reverse transcriptase lacks proof-rea...
AbstractObjectivesDetection of mutations associated to nucleos(t)ide analogs and hepatitis B virus (...
Resistance to anti-viral drugs is a global problem in the treatment of HBV. Around 350 million peopl...
Background: Hepatitis B Virus (HBV) infection is one of the major causes of liver cirrhosis, hepatoc...
TEZ10647Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2014.Kaynakça (s. 102-111) var.xii, 112...
AbstractDirect sequencing and reverse hybridization are currently the main methods for detecting dru...
Direct population sequencing and reverse hybridization (line probe assay [LiPA])-based methods are t...
The dynamics of emerging nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI) resistance...
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therap...
Although the advent of ultra-deep sequencing technology allows for the analysis of heretofore-undete...
Monitoring of drug resistance mutations in Hepatitis B virus (HBV) is critical for the management of...
BACKGROUND: Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog...
BACKGROUND AND AIMS: Although the advent of ultra-deep sequencing technology allows for the analysis...
WOS: 000463053800023Introduction: The development of drug resistance mutations to nucleos(t)ide anal...
International audienceHepatitis B virus (HBV) resistance to nucleoside/nucleotide analogs is frequen...
HBV DNA replicates through a genomic RNA intermediate. The HBV reverse transcriptase lacks proof-rea...
AbstractObjectivesDetection of mutations associated to nucleos(t)ide analogs and hepatitis B virus (...
Resistance to anti-viral drugs is a global problem in the treatment of HBV. Around 350 million peopl...
Background: Hepatitis B Virus (HBV) infection is one of the major causes of liver cirrhosis, hepatoc...
TEZ10647Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2014.Kaynakça (s. 102-111) var.xii, 112...