A new regulator of the vacuolar H+-ATPase in the kidney

Xu et al. identify Slc26a11, a novel member of the Slc26 anion exchanger family, as an electrogenic (Cl−)n/HCO3− exchanger. Functional characterization of this transporter suggests that Slc26a11 mediates classical electroneutral Cl−/HCO3− exchange but also exhibits an electrogenic Cl− conductance. In the kidney, Slc26a11 colocalizes with the vacuolar H+-ATPase in intercalated cells, emphasizing the cooperation of the proton pump with chloride transporters