AbstractNeuronal exocytosis is mediated by a Ca2+-triggered membrane fusion event that joins synaptic vesicles and presynaptic membrane. In this event, synaptotagmin I plays a key role as a Ca2+ sensor protein that binds to and bends the presynaptic membrane with its C2B domain, and thereby initiates membrane fusion. We report free energy calculations according to which C2B-induced membrane bending is preceded by a Ca2+- and membrane-dependent conformational transition. In this transition C2B attaches to the membrane, moves its C-terminal helix from the orientation seen in the available (but membrane-free) crystal/NMR structures as pointing away from the membrane (helix-up), to an orientation pointing toward the membrane (helix-down). In th...
The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membra...
Intrinsically disordered proteins (IDPs) and their conformational transitions play an important role...
Upon arrival of an action potential at the neuronal synapse, calcium ions (Ca2+) enter the neuron, a...
AbstractNeuronal exocytosis is mediated by a Ca2+-triggered membrane fusion event that joins synapti...
AbstractIn the current understanding of exocytosis at the nerve terminal, the C2 domain of synaptota...
SummaryDecades ago it was proposed that exocytosis involves invagination of the target membrane, res...
AbstractSynaptotagmin triggers rapid exocytosis of neurotransmitters from synaptic vesicles in respo...
Synaptotagmin-1 (Syt1) is a calcium sensor protein that is critical for neurotransmission and is the...
AbstractSynaptotagmin 1 (Syt1) is a synaptic vesicle protein that serves as a calcium sensor of neur...
AbstractMembrane fusion requires that nearly flat lipid bilayers deform into shapes with very high c...
AbstractSynaptotagmin I is the major Ca2+ sensor for membrane fusion during neurotransmitter release...
A l’arrivée d’un potentiel d’action au niveau d’une synapse neuronale, des ions calcium (Ca2+) pénèt...
Fast synchronous neurotransmitter release is triggered by calcium that activates synaptotagmin-1 (...
Synaptotagmin-1 functions as a Ca2+ sensor in neurotransmitter release, and was proposed to act on b...
Synapotagmin-1 (Syt1) interacts with both SNARE proteins and lipid membranes to synchronize neurotra...
The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membra...
Intrinsically disordered proteins (IDPs) and their conformational transitions play an important role...
Upon arrival of an action potential at the neuronal synapse, calcium ions (Ca2+) enter the neuron, a...
AbstractNeuronal exocytosis is mediated by a Ca2+-triggered membrane fusion event that joins synapti...
AbstractIn the current understanding of exocytosis at the nerve terminal, the C2 domain of synaptota...
SummaryDecades ago it was proposed that exocytosis involves invagination of the target membrane, res...
AbstractSynaptotagmin triggers rapid exocytosis of neurotransmitters from synaptic vesicles in respo...
Synaptotagmin-1 (Syt1) is a calcium sensor protein that is critical for neurotransmission and is the...
AbstractSynaptotagmin 1 (Syt1) is a synaptic vesicle protein that serves as a calcium sensor of neur...
AbstractMembrane fusion requires that nearly flat lipid bilayers deform into shapes with very high c...
AbstractSynaptotagmin I is the major Ca2+ sensor for membrane fusion during neurotransmitter release...
A l’arrivée d’un potentiel d’action au niveau d’une synapse neuronale, des ions calcium (Ca2+) pénèt...
Fast synchronous neurotransmitter release is triggered by calcium that activates synaptotagmin-1 (...
Synaptotagmin-1 functions as a Ca2+ sensor in neurotransmitter release, and was proposed to act on b...
Synapotagmin-1 (Syt1) interacts with both SNARE proteins and lipid membranes to synchronize neurotra...
The Ca2+-sensor synaptotagmin-1 that triggers neuronal exocytosis binds to negatively charged membra...
Intrinsically disordered proteins (IDPs) and their conformational transitions play an important role...
Upon arrival of an action potential at the neuronal synapse, calcium ions (Ca2+) enter the neuron, a...