The Skin as a Site of Initiation of Systemic Autoimmune Disease: New Opportunities for Treatment
- Dutz, Jan P.
Publication date
June 2006
DOI Publisher
The Society for Investigative Dermatology, Inc. ISSN
0022-202XAbstract
Dendritic cells are the coordinators of the adaptive immune response. Chronic activation of skin dendritic cells by keratinocyte expression of CD40 ligand (CD40L; CD154) leads to autoimmunity. In this issue, systemic administration of tacrolimus is shown by Loser et al. to effectively treat autoimmunity in a murine model involving transgenic keratinocyte expression of CD40L
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