Diastolic function parameters are improved by the addition of simvastatin to enalapril-based treatment in hypertensive individuals
- Beck, Adenalva L.S.
- Otto, Maria E.B.
- D′Avila, Luciana B.O.
- Netto, Fernando M.
- Armendaris, Marinez K.
- Sposito, Andrei C.
DOIAbstract
AbstractObjectiveDiastolic dysfunction (DD) is a frequent condition in hypertensive patients whose presence increases mortality and whose treatment remains unclear. The aim of this study was to investigate in a prospective, double-blinded, placebo-controlled randomized design the additive effect of simvastatin on DD in enalapril-treated hypertensive patients with average cholesterol levels.MethodsHypertensive patients with DD and LDL-cholesterol <160mg/dL underwent a run-in phase to achieve a systolic blood pressure (SBP) <135mmHg and diastolic blood pressure (DBP) <85mmHg with enalapril. Hydrochlorothiazide was added when need to achieve blood pressure control. Four weeks after reaching the optimum anti-hypertensive regimen patients were r...