CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al. (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation
AbstractN-7 and 2′-O methylation of host cell mRNA occurs in the nucleus and results in the generati...
RNA is subject to a wide array of post-transcriptional modifications. 2'-O-methylation is an essenti...
The integration of chromatin modifiers into specific regulatory networks is not fully understood. In...
CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, ...
SummaryDNA and RNA stimulate the mammalian innate immune system through activation of Toll-like rece...
International audienceSensing of nucleic acids for molecular discrimination between self and non-sel...
Bacterial and viral RNA are potent stimulators of the innate immune system, leading to im-mune cell ...
TLR7 and TLR8 recognize RNA from pathogens and lead to subsequent immune stimulation. Here we demons...
The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartmen...
The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of vi...
Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gen...
The incorporation of modified nucleotides into ribonucleic acids (RNAs) is important for their struc...
SummaryThe cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to m...
AbstractThe Regulation of TLR7 and TLR9 in the Prevention of AutoimmunityByZachary Robert NewmanDoct...
The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. ...
AbstractN-7 and 2′-O methylation of host cell mRNA occurs in the nucleus and results in the generati...
RNA is subject to a wide array of post-transcriptional modifications. 2'-O-methylation is an essenti...
The integration of chromatin modifiers into specific regulatory networks is not fully understood. In...
CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, ...
SummaryDNA and RNA stimulate the mammalian innate immune system through activation of Toll-like rece...
International audienceSensing of nucleic acids for molecular discrimination between self and non-sel...
Bacterial and viral RNA are potent stimulators of the innate immune system, leading to im-mune cell ...
TLR7 and TLR8 recognize RNA from pathogens and lead to subsequent immune stimulation. Here we demons...
The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartmen...
The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of vi...
Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gen...
The incorporation of modified nucleotides into ribonucleic acids (RNAs) is important for their struc...
SummaryThe cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to m...
AbstractThe Regulation of TLR7 and TLR9 in the Prevention of AutoimmunityByZachary Robert NewmanDoct...
The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. ...
AbstractN-7 and 2′-O methylation of host cell mRNA occurs in the nucleus and results in the generati...
RNA is subject to a wide array of post-transcriptional modifications. 2'-O-methylation is an essenti...
The integration of chromatin modifiers into specific regulatory networks is not fully understood. In...
DOI
Add to ORKG