AbstractP59 is the Trp-rich 20-mer peptide (767L–G786), partial sequence of the membrane-proximal external region (MPER) of the FIV gp36. It has potent antiviral activity, possibly due to a mechanism that inhibits the fusion of the virus with the cell membranes. In the hypothesis that a lipophilic tail could enhance the adhesion of P59 to the membrane so improving its antiviral activity, we synthesized its lipoylated analogue lipo-P59. Fluorescence, CD and NMR investigations in membrane mimicking environments (such as SDS and DPC micelles) were aimed to assess the potential of the lipo-P59 lipophilic tail to affect the biophysical and conformational behaviour of the peptide. In vitro inhibitory assays using lymphoid cell cultures to check t...
The immunogenicity of a lipoylated peptide (lipo-P59) reproducing the membrane-proximal external reg...
In a previous paper (Lombardi et at., Virology 220, 274-284, 1996), we reported that a 20-amino acid...
Feline immunodeficiency virus (FIV) is a pathogen that causes an AIDS-like syndrome in domestic cats...
AbstractP59 is the Trp-rich 20-mer peptide (767L–G786), partial sequence of the membrane-proximal ex...
P59 is the Trp-rich 20-mer peptide (767L–G786), partial sequence of the membrane-proximal external r...
P59, a 20-mer peptide modeled on the membrane-proximal external region (MPER) of the feline immunode...
P59, a 20-mer peptide modelled on the membrane-proximal external region (MPER) of the FIV gp36 ectod...
Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodefic...
Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodefic...
AbstractC8, a short peptide characterized by three regularly spaced Trp residues, belongs to the mem...
AbstractSixty-six 20- to 23-amino-acid synthetic peptides, partially overlapping by 10–12 amino acid...
The interactions between proteins/peptides and lipid bilayers are fundamental in a variety of key bi...
The interactions between peptides and lipid bilayers are fundamental in a variety of key biological ...
AbstractThe interactions between proteins/peptides and lipid bilayers are fundamental in a variety o...
The immunogenicity of a lipoylated peptide (lipo-P59) reproducing the membrane-proximal external reg...
In a previous paper (Lombardi et at., Virology 220, 274-284, 1996), we reported that a 20-amino acid...
Feline immunodeficiency virus (FIV) is a pathogen that causes an AIDS-like syndrome in domestic cats...
AbstractP59 is the Trp-rich 20-mer peptide (767L–G786), partial sequence of the membrane-proximal ex...
P59 is the Trp-rich 20-mer peptide (767L–G786), partial sequence of the membrane-proximal external r...
P59, a 20-mer peptide modeled on the membrane-proximal external region (MPER) of the feline immunode...
P59, a 20-mer peptide modelled on the membrane-proximal external region (MPER) of the FIV gp36 ectod...
Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodefic...
Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodefic...
AbstractC8, a short peptide characterized by three regularly spaced Trp residues, belongs to the mem...
AbstractSixty-six 20- to 23-amino-acid synthetic peptides, partially overlapping by 10–12 amino acid...
The interactions between proteins/peptides and lipid bilayers are fundamental in a variety of key bi...
The interactions between peptides and lipid bilayers are fundamental in a variety of key biological ...
AbstractThe interactions between proteins/peptides and lipid bilayers are fundamental in a variety o...
The immunogenicity of a lipoylated peptide (lipo-P59) reproducing the membrane-proximal external reg...
In a previous paper (Lombardi et at., Virology 220, 274-284, 1996), we reported that a 20-amino acid...
Feline immunodeficiency virus (FIV) is a pathogen that causes an AIDS-like syndrome in domestic cats...