Expression of protein kinase C subspecies in human leukemia- lymphoma cell lines
- Sawamura, Satoru
- Ase, Katsuhiko
- Berry, Nicola
- Kikkawa, Ushio
- McCaffrey, Patricia G.
- Minowada, Jun
- Nishizuka, Yasutomi
Publication date
April 1989
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793 Citation count (estimate)
20Abstract
AbstractExpression of protein kinase C (PKC) subspecies was studied in various human leukemia-lymphoma cell lines. The PKC in most cell lines examined was resolved into two major fractions corresponding to type II (β-sequence) and type III (α-sequence) PKC of the rat brain. The amounts of these two subspecies greatly varied among the cell lines. Type I PKC (γ-sequence) was expressed in none of the cell lines tested, but PKCs with undefined structures were frequently detected. The differential co-expression of several PKC subspecies is presumably related to the state of cell differentiation
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