AbstractBacterial biofilms play an important role in the persistent colonization of the respiratory tract in cystic fibrosis (CF) patients. The trade‐offs among planktonic or sessile modes of growth, mutation frequency, antibiotic susceptibility and mutant prevention concentrations (MPCs) were studied in a well‐defined collection of 42 CF Pseudomonas aeruginosa isolates. MICs of ciprofloxacin, tobramycin, imipenem and ceftazidime increased in the biofilm mode of growth, but not the MPCs of the same drugs. The mutation frequency median was significantly higher in planktonic conditions (1.1 × 10−8) than in biofilm (9.9 × 10−9) (p 0.015). Isolates categorized as hypomutable increased their mutation frequency from 3.6 × 10−9 in the planktonic m...
AbstractBackgroundBacteria grow as biofilms within CF airways. However, antibiotic susceptibility te...
Cystic fibrosis (CF) is a human genetic disorder which results in a lung environment that is highly ...
Pseudomonas aeruginosa chronic infections are the major cause of high morbidity and mortality in cys...
AbstractBacterial biofilms play an important role in the persistent colonization of the respiratory ...
Bacterial biofilms play an important role in the persistent colonization of the respiratory tract in...
Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmen...
Bacterial infections caused mainly by P. aeruginosa are typical of cystic fibrosis (CF) lung disease...
Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmen...
Bacterial infections in cystic fibrosis (CF) lungs are generally associated with mucoid P. aeruginos...
Distinct availabilities of oxygen, nutrients and antibiotics in the cystic fibrosis (CF) airways hav...
Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung disease. Its lon...
Cystic Fibrosis (CF) is characterized by high rates of morbidity and mortality caused by pulmonary m...
It has been widely demonstrated that different predisposing “local environmental” conditions exist w...
Chronic lung infection with P. aeruginosa is the major cause of morbidity and mortality in cystic fi...
Pseudomonas aeruginosa is the dominant pathogen associated with bacterial infections occurring in Cy...
AbstractBackgroundBacteria grow as biofilms within CF airways. However, antibiotic susceptibility te...
Cystic fibrosis (CF) is a human genetic disorder which results in a lung environment that is highly ...
Pseudomonas aeruginosa chronic infections are the major cause of high morbidity and mortality in cys...
AbstractBacterial biofilms play an important role in the persistent colonization of the respiratory ...
Bacterial biofilms play an important role in the persistent colonization of the respiratory tract in...
Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmen...
Bacterial infections caused mainly by P. aeruginosa are typical of cystic fibrosis (CF) lung disease...
Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmen...
Bacterial infections in cystic fibrosis (CF) lungs are generally associated with mucoid P. aeruginos...
Distinct availabilities of oxygen, nutrients and antibiotics in the cystic fibrosis (CF) airways hav...
Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung disease. Its lon...
Cystic Fibrosis (CF) is characterized by high rates of morbidity and mortality caused by pulmonary m...
It has been widely demonstrated that different predisposing “local environmental” conditions exist w...
Chronic lung infection with P. aeruginosa is the major cause of morbidity and mortality in cystic fi...
Pseudomonas aeruginosa is the dominant pathogen associated with bacterial infections occurring in Cy...
AbstractBackgroundBacteria grow as biofilms within CF airways. However, antibiotic susceptibility te...
Cystic fibrosis (CF) is a human genetic disorder which results in a lung environment that is highly ...
Pseudomonas aeruginosa chronic infections are the major cause of high morbidity and mortality in cys...