During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death
Diabetes is an epidemic of worldwide proportions caused by β -cell failure. Nutrient fluctuations a...
Uncontrolled endoplasmic reticulum (ER) stress responses are proposed to contribute to the pathology...
In pancreatic β cells, the endoplasmic reticulum (ER) is an important cellular compartment for insul...
During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell...
SummaryWhen unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulu...
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The pathogenesis...
SummaryRecent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress con...
The accumulation of unfolded protein in the endoplasmic reticulum (ER) causes ER stress. Cells acti...
BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway cli...
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive p...
Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to ...
Type 2 diabetes (T2D) is a disease that is characterized by raised levels of glucose in the blood co...
Diabetes mellitus is a disease caused by a combination of insulin resistance and decline of &bet...
Endoplasmic reticulum (ER) stress caused by perturbations in ER homeostasis activates an adaptive re...
In pancreatic beta-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesi...
Diabetes is an epidemic of worldwide proportions caused by β -cell failure. Nutrient fluctuations a...
Uncontrolled endoplasmic reticulum (ER) stress responses are proposed to contribute to the pathology...
In pancreatic β cells, the endoplasmic reticulum (ER) is an important cellular compartment for insul...
During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell...
SummaryWhen unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulu...
Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. The pathogenesis...
SummaryRecent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress con...
The accumulation of unfolded protein in the endoplasmic reticulum (ER) causes ER stress. Cells acti...
BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway cli...
Type 1 diabetes (T1D) is an autoimmune disease characterized by islet inflammation and progressive p...
Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to ...
Type 2 diabetes (T2D) is a disease that is characterized by raised levels of glucose in the blood co...
Diabetes mellitus is a disease caused by a combination of insulin resistance and decline of &bet...
Endoplasmic reticulum (ER) stress caused by perturbations in ER homeostasis activates an adaptive re...
In pancreatic beta-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesi...
Diabetes is an epidemic of worldwide proportions caused by β -cell failure. Nutrient fluctuations a...
Uncontrolled endoplasmic reticulum (ER) stress responses are proposed to contribute to the pathology...
In pancreatic β cells, the endoplasmic reticulum (ER) is an important cellular compartment for insul...
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