AbstractBiological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the unfavorable interaction between the lining of a hydrophobic pore and water may lead to stochastic liquid–vapor transitions. These transient vapor states are “dewetted”, i.e. effectively devoid of water molecules within all or part of the pore, thus leading to an energetic barrier to ion conduction. This process, termed “hydrophobic gating”, was first observed in molecular dynamics simulations of model nanopores, where the principles underlying hydrophobic gating (i.e., changes in diamet...
A hydrophobic constriction site can act as an efficient barrier to ion and water permeation if its d...
The gating mechanism of transmembrane ion channels is crucial for understanding how these proteins c...
Molecular dynamics simulations are carried out to determine the effects of channel wall structure on...
AbstractBiological ion channels are nanoscale transmembrane pores. When water and ions are enclosed ...
Water is at the heart of almost all biological phenomena, without which no life that we know of woul...
AbstractIon channels are gated, i.e. they can switch conformation between a closed and an open state...
AbstractThe dynamics of confined water in capillaries and nanotubes suggests that gating of ion chan...
AbstractThe theoretical prediction of water drying transitions near nonpolar surfaces has stimulated...
AbstractNarrow hydrophobic regions are a common feature of biological channels, with possible roles ...
Water molecules within biological ion channels are in a nanoconfined environment and therefore exhib...
Water-filled pores of nanometer dimensions play important roles in chemistry and biology, e.g., as c...
Ion channel proteins form nanopores in biological membranes which allow the passage of ions and wate...
<p>Ion channels such as the nicotinic acetylcholine receptor (nAChR) fulfil essential roles in fast ...
Ion channel proteins control ionic flux across biological membranes through conformational changes i...
Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit ...
A hydrophobic constriction site can act as an efficient barrier to ion and water permeation if its d...
The gating mechanism of transmembrane ion channels is crucial for understanding how these proteins c...
Molecular dynamics simulations are carried out to determine the effects of channel wall structure on...
AbstractBiological ion channels are nanoscale transmembrane pores. When water and ions are enclosed ...
Water is at the heart of almost all biological phenomena, without which no life that we know of woul...
AbstractIon channels are gated, i.e. they can switch conformation between a closed and an open state...
AbstractThe dynamics of confined water in capillaries and nanotubes suggests that gating of ion chan...
AbstractThe theoretical prediction of water drying transitions near nonpolar surfaces has stimulated...
AbstractNarrow hydrophobic regions are a common feature of biological channels, with possible roles ...
Water molecules within biological ion channels are in a nanoconfined environment and therefore exhib...
Water-filled pores of nanometer dimensions play important roles in chemistry and biology, e.g., as c...
Ion channel proteins form nanopores in biological membranes which allow the passage of ions and wate...
<p>Ion channels such as the nicotinic acetylcholine receptor (nAChR) fulfil essential roles in fast ...
Ion channel proteins control ionic flux across biological membranes through conformational changes i...
Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit ...
A hydrophobic constriction site can act as an efficient barrier to ion and water permeation if its d...
The gating mechanism of transmembrane ion channels is crucial for understanding how these proteins c...
Molecular dynamics simulations are carried out to determine the effects of channel wall structure on...