SummaryThe axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead to MAP activation, but specific molecular pathways have remained elusive. We find that Spinophilin, a Protein-phosphatase 1 (PP1) targeting protein, is responsible for the dephosphorylation of the MAP Doublecortin (Dcx) Ser 297 selectively at the “wrist” of growing axons, leading to activation. Loss of activity at the “wrist” is evident as an impaired microtubule cytoskeleton along the shaft. These findings suggest that s...
Dynamic regulation of neuronal cytoskeletal machinery in response to extracellular cues enables dist...
SummaryThe mechanisms controlling neurogenesis during brain development remain relatively unknown. T...
AbstractDoublecortin (DCX) is a microtubule-associated protein that interacts with and regulates the...
The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain un...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
AbstractDoublecortin (Dcx) is a microtubule-associated protein that is mutated in X-linked lissencep...
© 2019 Maryam MoslehiX-linked Doublecortin (DCX) is a 40 kDa neuron-specific microtubule (MT)-associ...
Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to the cerebr...
Microtubules and actin are two essential cytoskeletal networks in neurons, providing structural supp...
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory sy...
AbstractMutations in the doublecortin (DCX) gene in human or targeted disruption of the cdk5 gene in...
Doublecortin X (DCX) plays essential roles in neuronal development via its regulation of cytoskeleto...
Doublecortin (DCX), a microtubule-associated protein, is essential for neuronal migration, although ...
Mutations in the human Doublecortin (DCX) gene cause X-linked lissencephaly, a neuronal migration di...
Dynamic regulation of neuronal cytoskeletal machinery in response to extracellular cues enables dist...
SummaryThe mechanisms controlling neurogenesis during brain development remain relatively unknown. T...
AbstractDoublecortin (DCX) is a microtubule-associated protein that interacts with and regulates the...
The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain un...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
A new study has shown that, near the tip of a growing axon, dephosphorylation of the microtubule-ass...
AbstractDoublecortin (Dcx) is a microtubule-associated protein that is mutated in X-linked lissencep...
© 2019 Maryam MoslehiX-linked Doublecortin (DCX) is a 40 kDa neuron-specific microtubule (MT)-associ...
Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to the cerebr...
Microtubules and actin are two essential cytoskeletal networks in neurons, providing structural supp...
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory sy...
AbstractMutations in the doublecortin (DCX) gene in human or targeted disruption of the cdk5 gene in...
Doublecortin X (DCX) plays essential roles in neuronal development via its regulation of cytoskeleto...
Doublecortin (DCX), a microtubule-associated protein, is essential for neuronal migration, although ...
Mutations in the human Doublecortin (DCX) gene cause X-linked lissencephaly, a neuronal migration di...
Dynamic regulation of neuronal cytoskeletal machinery in response to extracellular cues enables dist...
SummaryThe mechanisms controlling neurogenesis during brain development remain relatively unknown. T...
AbstractDoublecortin (DCX) is a microtubule-associated protein that interacts with and regulates the...