Skeletal abnormalities in chronic renal insufficiency before and during maintenance hemodialysis

“One cannot understand bone disease without studying bone itself” (S. W. Stanbury).Chronic renal insufficiency is associated with a peculiar form of bone disease, the pathogenesis of which has not yet been completely clarified [1], Since the lives of patients in terminal renal insufficiency can now be prolonged by maintenance hemodialysis and renal homotransplantation, the problem of uremic bone disease has attracted considerable interest and remains one of the major unsolved problems of maintenance hemodialysis. In the present report, we utilize our own data [2-5] to discuss the clinical signs, X-ray manifestations and the histological abnormalities of the skeleton in patients with renal failure