Introduction:Anaplastic lymphoma kinase (ALK) rearrangements are present in an important subset of non–small-cell lung cancer (NSCLC) and predict for response to the tyrosine kinase inhibitor crizotinib. In this study, we evaluated the yet unknown frequency and functional role of ALK splicing isoforms in NSCLC.Methods:We analyzed 270 cases of NSCLC for ALK kinase domain splicing aberrations and in addition generated constructs with full-length echinoderm microtubule-associated protein-like 4 (EML4)-ALK (E13;A20) and a splicing isoform.Results:Splicing isoforms of the kinase domain of ALK—including complete skipping of exon 23 (ALKdel23, ALK p.I1171fs*42) and exon 27 (ALKdel27, ALK p.T1312fs*0)—were identified in 11.1% (30 of 270 cases) of N...
Anaplastic lymphoma kinase (ALK) can mediate transformation through activation by various genetic me...
BACKGROUND: Clinical outcomes of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung can...
Acquired secondary mutations in the anaplastic lymphoma kinase (ALK) gene have been identified in AL...
Introduction:Anaplastic lymphoma kinase (ALK) rearrangements are present in an important subset of n...
INTRODUCTION: Anaplastic lymphoma kinase (ALK) rearrangements are present in an important subset...
Introduction:Translocation of the anaplastic lymphoma kinase (ALK) gene is involved in the tumorigen...
Introduction:The aim of this study was to identify anaplastic lymphoma kinase (ALK) rearrangements i...
It was only 3 years ago that an acquired translocation of EML4 with ALK leading to the expression of...
AbstractTransforming rearrangements of the ALK (anaplastic lymphoma kinase) gene have recently been ...
IntroductionOncogenic ALK kinase activity associated with ALK gene rearrangement is the target of cr...
AbstractThe oncogenic property of anaplastic lymphoma kinase (ALK) plays an essential role in the pa...
Introduction:The report of cases of lung squamous cell cancers harboring anaplastic lymphoma kinase ...
Background: This study aimed to elucidate clinical significance of anaplastic lymphoma kinase (ALK) ...
Context. - Echinoderm microtubule associated protein-like 4-anaplastic lymphoma receptor tyrosine ki...
AbstractThe echinoderm microtubule–associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) f...
Anaplastic lymphoma kinase (ALK) can mediate transformation through activation by various genetic me...
BACKGROUND: Clinical outcomes of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung can...
Acquired secondary mutations in the anaplastic lymphoma kinase (ALK) gene have been identified in AL...
Introduction:Anaplastic lymphoma kinase (ALK) rearrangements are present in an important subset of n...
INTRODUCTION: Anaplastic lymphoma kinase (ALK) rearrangements are present in an important subset...
Introduction:Translocation of the anaplastic lymphoma kinase (ALK) gene is involved in the tumorigen...
Introduction:The aim of this study was to identify anaplastic lymphoma kinase (ALK) rearrangements i...
It was only 3 years ago that an acquired translocation of EML4 with ALK leading to the expression of...
AbstractTransforming rearrangements of the ALK (anaplastic lymphoma kinase) gene have recently been ...
IntroductionOncogenic ALK kinase activity associated with ALK gene rearrangement is the target of cr...
AbstractThe oncogenic property of anaplastic lymphoma kinase (ALK) plays an essential role in the pa...
Introduction:The report of cases of lung squamous cell cancers harboring anaplastic lymphoma kinase ...
Background: This study aimed to elucidate clinical significance of anaplastic lymphoma kinase (ALK) ...
Context. - Echinoderm microtubule associated protein-like 4-anaplastic lymphoma receptor tyrosine ki...
AbstractThe echinoderm microtubule–associated protein-like 4–anaplastic lymphoma kinase (EML4-ALK) f...
Anaplastic lymphoma kinase (ALK) can mediate transformation through activation by various genetic me...
BACKGROUND: Clinical outcomes of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung can...
Acquired secondary mutations in the anaplastic lymphoma kinase (ALK) gene have been identified in AL...