Possible Genetic Control of the Proportions of Branched-Chain Fatty Acids in Human Sebaceous Wax Esters

The composition of human sebum varies among individuals with respect to the proportions of various types of fatty acids in the ester lipid classes. Iso-branched fatty acids with even numbers of carbons (iso-even) are particularly variable. However, in 13 identical twin pairs, intrapair differences in the proportions of iso-even fatty acids in sebaceous wax esters were found to be very small, while interpair differences were as large as in the nontwin population. Intrapair differences in iso-even fatty acids were also quite small in 4 of 8 fraternal twin pairs. Heritability estimates suggested that proportions of iso-even fatty acids in human sebum are controlled, at least in part, by genotype