TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this issue of Immunity, Hasan et al. (2015) show that TREX1 also safeguards the cell against free glycan build-up in the endoplasmic reticulum, thereby preventing glycan-induced inflammation
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms...
SummaryThe plasma membrane and all membrane-bound organelles except for the Golgi and endoplasmic re...
SummaryStimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for ho...
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this is...
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabol...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
Endoplasmic reticulum (ER) stress plays a major role in several inflammatory disorders. ER stress in...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory ...
Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condit...
<div><p><i>Brucella melitensis</i> is a facultative intracellular bacterium that causes brucellosis,...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms...
SummaryThe plasma membrane and all membrane-bound organelles except for the Golgi and endoplasmic re...
SummaryStimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for ho...
TREX1 regulates innate immune responses by counteracting DNA accumulation in the cytosol. In this is...
SummaryTREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX...
Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which acti...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. ...
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabol...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
Endoplasmic reticulum (ER) stress plays a major role in several inflammatory disorders. ER stress in...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory ...
Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condit...
<div><p><i>Brucella melitensis</i> is a facultative intracellular bacterium that causes brucellosis,...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms...
SummaryThe plasma membrane and all membrane-bound organelles except for the Golgi and endoplasmic re...
SummaryStimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for ho...
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