The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids once all chromosomes are attached via kinetochores by microtubules of the mitotic spindle. Reporting in Developmental Cell, Silió et al. (2015) show that in human cells the signaling cascade controlling the checkpoint operates through two separate branches
AbstractTo segregate chromosomes during cell division, microtubules that form the bipolar spindle at...
SummaryCompromising the activity of the spindle checkpoint permits mitotic exit in the presence of u...
The kinetochore is the major attachment site between chromosomes and microtubules during mitosis but...
SummaryThe spindle assembly checkpoint (SAC) ensures the accurate segregation of sister chromatids d...
The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids on...
The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids on...
The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids on...
Equal distribution of replicated genetic materials packed in chromosomes from a dividing parent cell...
To maintain genomic integrity, the Spindle Assembly Checkpoint (SAC) prevents anaphase onset until a...
The spindle assembly checkpoint (SAC) ensures the accurate segregation of sister chromatids during m...
AbstractAccurate chromosome segregation relies on the precise regulation of mitotic progression. Reg...
The kinetochore is a remarkable protein machine that links chromosomes to mitotic spindle microtubul...
The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression dur...
Cell division allows the passage of genetic information to a new cell. During this process, maintai...
The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly checkpoint (SAC), which contr...
AbstractTo segregate chromosomes during cell division, microtubules that form the bipolar spindle at...
SummaryCompromising the activity of the spindle checkpoint permits mitotic exit in the presence of u...
The kinetochore is the major attachment site between chromosomes and microtubules during mitosis but...
SummaryThe spindle assembly checkpoint (SAC) ensures the accurate segregation of sister chromatids d...
The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids on...
The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids on...
The spindle assembly checkpoint ensures that mitotic cells only segregate their sister chromatids on...
Equal distribution of replicated genetic materials packed in chromosomes from a dividing parent cell...
To maintain genomic integrity, the Spindle Assembly Checkpoint (SAC) prevents anaphase onset until a...
The spindle assembly checkpoint (SAC) ensures the accurate segregation of sister chromatids during m...
AbstractAccurate chromosome segregation relies on the precise regulation of mitotic progression. Reg...
The kinetochore is a remarkable protein machine that links chromosomes to mitotic spindle microtubul...
The spindle assembly checkpoint is a safeguard mechanism that coordinates cell-cycle progression dur...
Cell division allows the passage of genetic information to a new cell. During this process, maintai...
The Mad1-Mad2 heterodimer is the catalytic hub of the spindle assembly checkpoint (SAC), which contr...
AbstractTo segregate chromosomes during cell division, microtubules that form the bipolar spindle at...
SummaryCompromising the activity of the spindle checkpoint permits mitotic exit in the presence of u...
The kinetochore is the major attachment site between chromosomes and microtubules during mitosis but...
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