Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
- Kerkhof, H.J.M.
- Meulenbelt, I.
- Akune, T.
- Arden, N.K.
- Aromaa, A.
- Bierma-Zeinstra, S.M.A.
- Carr, A.
- Cooper, C.
- Dai, J.
- Doherty, M.
- Doherty, S.A.
- Felson, D.
- Gonzalez, A.
- Gordon, A.
- Harilainen, A.
- Hart, D.J.
- Hauksson, V.B.
- Heliovaara, M.
- Hofman, A.
- Ikegawa, S.
- Ingvarsson, T.
- Jiang, Q.
- Jonsson, H.
- Jonsdottir, I.
- Kawaguchi, H.
- Kloppenburg, M.
- Kujala, U.M.
- Lane, N.E.
- Leino-Arjas, P.
- Lohmander, L.S.
- Luyten, F.P.
- Malizos, K.N.
- Nakajima, M.
- Nevitt, M.C.
- Pols, H.A.P.
- Rivadeneira, F.
- Shi, D.
- Slagboom, E.
- Spector, T.D.
- Stefansson, K.
- Sudo, A.
- Tamm, A.
- Tamm, A.E.
- Tsezou, A.
- Uchida, A.
- Uitterlinden, A.G.
- Wilkinson, J.M.
- Yoshimura, N.
- Valdes, A.M.
- van Meurs, J.B.J.
DOIAbstract
SummaryObjectiveTo address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes.MethodsDescriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study I (RSI)) and testing those for association with gender, age and body mass index using one-way ANOVA. For ROA, we standardized the hip-, knee- and hand ROA definitions and calculated prevalence’s of ROA before and after standardization in nine cohort stu...
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