Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation

  • Zenewicz, Lauren A.
  • Yancopoulos, George D.
  • Valenzuela, David M.
  • Murphy, Andrew J.
  • Karow, Margaret
  • Flavell, Richard A.
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Publication date
October 2007
Publisher
Elsevier Inc.
ISSN
1074-7613
Citation count (estimate)
478

Abstract

SummaryThe cytokine interleukin-22 (IL-22) is primarily expressed by T helper 17 (Th17) CD4+ T cells and is highly upregulated during chronic inflammatory diseases. IL-22 receptor expression is absent on immune cells, but is instead restricted to the tissues, providing signaling directionality from the immune system to the tissues. However, the role of IL-22 in inflammatory responses has been confounded by data suggesting both pro- and anti-inflammatory functions. Herein, we provide evidence that during inflammation, IL-22 played a protective role in preventing tissue injury. Hepatocytes from mice deficient in IL-22 were highly sensitive to the detrimental immune response associated with hepatitis. Additionally, IL-22-expressing Th17 cells ...

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