SummaryThe cytokine interleukin-22 (IL-22) is primarily expressed by T helper 17 (Th17) CD4+ T cells and is highly upregulated during chronic inflammatory diseases. IL-22 receptor expression is absent on immune cells, but is instead restricted to the tissues, providing signaling directionality from the immune system to the tissues. However, the role of IL-22 in inflammatory responses has been confounded by data suggesting both pro- and anti-inflammatory functions. Herein, we provide evidence that during inflammation, IL-22 played a protective role in preventing tissue injury. Hepatocytes from mice deficient in IL-22 were highly sensitive to the detrimental immune response associated with hepatitis. Additionally, IL-22-expressing Th17 cells ...
Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many w...
Objective: IL-22-producing CD4+ T helper cells (Th22 cells) have been identified as major inducers o...
Interleukin-22 (IL-22) is known to play a critical role in liver immunity. However, the role of IL-2...
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surfa...
Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine ...
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection affect >500 million people wor...
Interleukin (IL)-22, a member of the IL-10 cytokine family, plays critical roles in tissue repair an...
Abstract: IL-22 is a cytokine recently discovered to be produced by TH17 cells. Its receptor is expr...
AbstractInterleukin 22 (IL-22) is mainly produced by activated Th1 cells. The data presented here in...
Background&Aims Interleukin-22(IL-22)is up-regulated in liver tissues of patients with hepatitis...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads ...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads ...
Hepatitis B virus (HBV) infection remains a worldwide health problem, and is the major cause of hepa...
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and coloniz...
SummaryInflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated by ...
Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many w...
Objective: IL-22-producing CD4+ T helper cells (Th22 cells) have been identified as major inducers o...
Interleukin-22 (IL-22) is known to play a critical role in liver immunity. However, the role of IL-2...
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surfa...
Interleukin-22 (IL-22) is a pluripotent T cell-derived cytokine which is a member of IL-10 cytokine ...
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection affect >500 million people wor...
Interleukin (IL)-22, a member of the IL-10 cytokine family, plays critical roles in tissue repair an...
Abstract: IL-22 is a cytokine recently discovered to be produced by TH17 cells. Its receptor is expr...
AbstractInterleukin 22 (IL-22) is mainly produced by activated Th1 cells. The data presented here in...
Background&Aims Interleukin-22(IL-22)is up-regulated in liver tissues of patients with hepatitis...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads ...
Hepatocellular carcinoma (HCC) ranks among the five most common cancer entities worldwide and leads ...
Hepatitis B virus (HBV) infection remains a worldwide health problem, and is the major cause of hepa...
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and coloniz...
SummaryInflammatory bowel disease (IBD) is a chronic inflammatory disease thought to be mediated by ...
Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many w...
Objective: IL-22-producing CD4+ T helper cells (Th22 cells) have been identified as major inducers o...
Interleukin-22 (IL-22) is known to play a critical role in liver immunity. However, the role of IL-2...