Derived from the Greek roots allos and stereos, “allostery” literally means “other object.” Indeed, allosteric mechanisms are often overshadowed by the main action at the active site of an enzyme. This Structural Biology Select summarizes recent studies that highlight allostery's central role in fundamental cellular processes and in the development of new drugs
Bruton's tyrosine kinase (Btk) is a key component of BCR signaling required for B-cell maturation an...
Ever since when the mechanism of allosteric regulation was postulated for the first time in 1965 by ...
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymp...
The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukem...
BCR-ABL is the oncogenic protein-tyrosine kinase responsible for the pathogenesis of chronic myeloge...
Chronic myeloid leukemia (CML) is driven by the constitutive activity of the BCR-ABL1 fusion oncopro...
The c-Abl protein-tyrosine kinase regulates diverse cellular signaling pathways involved in cell gro...
Bcr-Abl is a constitutively active kinase that causes chronic myelogenous leukemia. We have shown th...
The emerging structural information about allosteric kinase complexes and the growing number of allo...
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymp...
AbstractRecently, a class of small molecules that thermally stabilize the tumor suppressor p53 was s...
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific ...
<div><p>The question of <i>how allostery works</i> was posed almost 50 years ago. Since then it has ...
Inhibition of Bcr-Abl kinase activity by imatinib for the treatment of chronic myeloid leukemia (CML...
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins ha...
Bruton's tyrosine kinase (Btk) is a key component of BCR signaling required for B-cell maturation an...
Ever since when the mechanism of allosteric regulation was postulated for the first time in 1965 by ...
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymp...
The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukem...
BCR-ABL is the oncogenic protein-tyrosine kinase responsible for the pathogenesis of chronic myeloge...
Chronic myeloid leukemia (CML) is driven by the constitutive activity of the BCR-ABL1 fusion oncopro...
The c-Abl protein-tyrosine kinase regulates diverse cellular signaling pathways involved in cell gro...
Bcr-Abl is a constitutively active kinase that causes chronic myelogenous leukemia. We have shown th...
The emerging structural information about allosteric kinase complexes and the growing number of allo...
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymp...
AbstractRecently, a class of small molecules that thermally stabilize the tumor suppressor p53 was s...
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific ...
<div><p>The question of <i>how allostery works</i> was posed almost 50 years ago. Since then it has ...
Inhibition of Bcr-Abl kinase activity by imatinib for the treatment of chronic myeloid leukemia (CML...
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins ha...
Bruton's tyrosine kinase (Btk) is a key component of BCR signaling required for B-cell maturation an...
Ever since when the mechanism of allosteric regulation was postulated for the first time in 1965 by ...
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymp...
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