In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key integrator of protein synthesis downstream of the ERK and AKT signaling pathways, providing an intriguing rationale for why their simultaneous targeting could enhance therapeutic efficacy
The development of cancer is an evolutionary process with accumulating (epi)genetic alterations unde...
AbstractThe life history of cancer cells encompasses a series of genetic missteps in which normal ce...
AbstractMany investigations have focused on how signaling pathways influence the transcription of sp...
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key ...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
SummaryPIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors ar...
© 2014 Dr. Jennifer Rose DevlinThe growth and proliferation of both normal and malignant cells is de...
The ability to translate genetic information into functional proteins is considered a landmark in ev...
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high...
Simple Summary Our work establishes that amplification of 4EBP1, as a part of Chr. 8p11, creates a s...
Deregulation of protein synthesis is a common event in human cancer and a key player in translationa...
The study of eukaryotic initiation factor 4E (eIF4E) is a key focus in cancer research due to its ro...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
SummaryBackgroundThe p53, Rb, and Ras/PI3K pathways are implicated in the development of the majorit...
Fulltext embargoed for: 12 months post date of publicationThe dysregulation of PI3K/AKT/mTORC1 signa...
The development of cancer is an evolutionary process with accumulating (epi)genetic alterations unde...
AbstractThe life history of cancer cells encompasses a series of genetic missteps in which normal ce...
AbstractMany investigations have focused on how signaling pathways influence the transcription of sp...
In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key ...
SummaryWe genetically dissect the contribution of the most prominent downstream translational compon...
SummaryPIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors ar...
© 2014 Dr. Jennifer Rose DevlinThe growth and proliferation of both normal and malignant cells is de...
The ability to translate genetic information into functional proteins is considered a landmark in ev...
The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high...
Simple Summary Our work establishes that amplification of 4EBP1, as a part of Chr. 8p11, creates a s...
Deregulation of protein synthesis is a common event in human cancer and a key player in translationa...
The study of eukaryotic initiation factor 4E (eIF4E) is a key focus in cancer research due to its ro...
Although it was first observed nearly a century ago that transformed cells are marked by enlarged nu...
SummaryBackgroundThe p53, Rb, and Ras/PI3K pathways are implicated in the development of the majorit...
Fulltext embargoed for: 12 months post date of publicationThe dysregulation of PI3K/AKT/mTORC1 signa...
The development of cancer is an evolutionary process with accumulating (epi)genetic alterations unde...
AbstractThe life history of cancer cells encompasses a series of genetic missteps in which normal ce...
AbstractMany investigations have focused on how signaling pathways influence the transcription of sp...
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