AbstractRetention of unspliced pre-messenger RNA (pre-mRNA) in the nucleus is essential for cell survival. Available nuclear factors must recognize and discern between diverse export signals present in pre-mRNA to establish an export inhibitory complex. We found that polypyrimidine domains present in both intron and exon were important for export inhibition of a minigene transcript based on hepatitis B virus pregenomic RNA. Overexpression of PTB drastically reduced export and presence of RRM4 domain seemed critical. This inhibitory network overrode stimulation from an exonic export-facilitating element. We posit that binding of PTB to multiple loci on pre-mRNA regulates nuclear retention
Alternative pre-mRNA splicing (AS) plays a major role in gene expression in higher eukaryotes, espec...
Review on PTBP1 (polypyrimidine tract binding protein 1), with data on DNA, on the protein encoded, ...
Over the last two decades, multiple studies have explored the mechanisms governing mRNA export out ...
AbstractPolypyrimidine-tract-binding protein (PTB) has been shown to bind specifically to the 5′ end...
Abstract.: The polypyrimidine tract binding protein (PTB) is a 58-kDa RNA binding protein involved i...
The overall processes of gene expression, from mRNA biogenesis to translation and degradation, requi...
Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein involved in s...
Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein involved in s...
Post-transcriptional control of gene expression is mediated by the interaction of RNA-binding protei...
The regulation of cap-independent translation directed by the internal ribosome entry sites (IRESs) ...
PTB (polypyrimidine-tract-binding protein) is a ubiquitous RNA-binding protein. It was originally id...
AbstractThe polypyrimidine tract binding protein (PTB) is an important regulator of alternative spli...
Polypyrimidine tract binding protein (PTB) is known to silence the splicing of many alternative exon...
We are using the rat beta-tropomyosin (beta-TM) gene as a model system to study the mechanism of alt...
AbstractThe ‘polypyrimidine-tract-binding protein’ (PTB) participates in the control of alternative ...
Alternative pre-mRNA splicing (AS) plays a major role in gene expression in higher eukaryotes, espec...
Review on PTBP1 (polypyrimidine tract binding protein 1), with data on DNA, on the protein encoded, ...
Over the last two decades, multiple studies have explored the mechanisms governing mRNA export out ...
AbstractPolypyrimidine-tract-binding protein (PTB) has been shown to bind specifically to the 5′ end...
Abstract.: The polypyrimidine tract binding protein (PTB) is a 58-kDa RNA binding protein involved i...
The overall processes of gene expression, from mRNA biogenesis to translation and degradation, requi...
Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein involved in s...
Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein involved in s...
Post-transcriptional control of gene expression is mediated by the interaction of RNA-binding protei...
The regulation of cap-independent translation directed by the internal ribosome entry sites (IRESs) ...
PTB (polypyrimidine-tract-binding protein) is a ubiquitous RNA-binding protein. It was originally id...
AbstractThe polypyrimidine tract binding protein (PTB) is an important regulator of alternative spli...
Polypyrimidine tract binding protein (PTB) is known to silence the splicing of many alternative exon...
We are using the rat beta-tropomyosin (beta-TM) gene as a model system to study the mechanism of alt...
AbstractThe ‘polypyrimidine-tract-binding protein’ (PTB) participates in the control of alternative ...
Alternative pre-mRNA splicing (AS) plays a major role in gene expression in higher eukaryotes, espec...
Review on PTBP1 (polypyrimidine tract binding protein 1), with data on DNA, on the protein encoded, ...
Over the last two decades, multiple studies have explored the mechanisms governing mRNA export out ...