Catalyst-free synthesis of benzodiazepines and benzimidazoles using glycerol as recyclable solvent

AbstractWe described herein the use of glycerol as solvent in the catalyst-free synthesis of benzodiazepines and benzimidazoles. This simple and efficient method furnishes the corresponding 1-H-1,5-benzodiazepines and 1,2-disubstituted benzimidazoles in good yields by the condensation of o-phenylenediamine with several ketones and aldehydes, respectively. In addition, glycerol can be easily re-utilized for further condensation reactions up to four times without lost of activity