Synthesis and antibacterial studies of 2-aryl-3-alkanamido-4H-thiazolidin-4-one derivatives

AbstractA series of 2-aryl-3-alkanamido-4H-thiazolidin-4-ones were synthesized from long chain fatty acid hydrazides and studied for their in vitro antibacterial activity. Long chain fatty acid hydrazides 1 on reaction with different aromatic aldehydes in the presence of catalytic amount of glacial acetic acid yielded the corresponding aryl hydrazones 2 which on further reaction with thioglycolic acid in the presence of anhydrous zinc chloride furnished the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were evaluated for their in vitro antibacterial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined