Chromosome segregation in eukaryotes requires a large molecular assembly termed the kinetochore to attach chromosomes to spindle microtubules. Recent work has made substantial progress in defining the composition and activities of the kinetochore, but much remains to be learned about its macromolecular structure. This commentary discusses recent insights into structural features of the kinetochore, how these inform our understanding of its biological function, and the key challenges for the future
Kinetochore attachment to spindle microtubule plus-ends is necessary for accurate chromosome segrega...
The fundamental property of living systems is their ability to consume resources from their environm...
The kinetochore is the protein machine built at the centromere that integrates mechanical force and ...
Chromosome segregation in eukaryotes requires a large molecular assembly termed the kinetochore to a...
Kinetochores are macromolecular complexes built on a specialized chromatin domain called the centrom...
The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryot...
SummaryDespite the identification of multiple kinetochore proteins, their structure and organization...
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic an...
During eukaryotic cell division, the sister chromatids of duplicated chromosomes are pulled apart by...
Kinetochores are enormous multiprotein complexes built on centromeric chromatin that link chromosome...
Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from t...
SummaryThe kinetochore is the macromolecular protein complex that directs chromosome segregation in ...
Kinetochores are highly specialized macromolecular machines built on top of centromeric chromatin to...
AbstractAccurate chromosome segregation is essential to ensure genomic stability because the aneuplo...
The kinetochore is a multi-protein complex that connects the chromosome with microtubule and pulls t...
Kinetochore attachment to spindle microtubule plus-ends is necessary for accurate chromosome segrega...
The fundamental property of living systems is their ability to consume resources from their environm...
The kinetochore is the protein machine built at the centromere that integrates mechanical force and ...
Chromosome segregation in eukaryotes requires a large molecular assembly termed the kinetochore to a...
Kinetochores are macromolecular complexes built on a specialized chromatin domain called the centrom...
The kinetochore is the macromolecular protein complex that drives chromosome segregation in eukaryot...
SummaryDespite the identification of multiple kinetochore proteins, their structure and organization...
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic an...
During eukaryotic cell division, the sister chromatids of duplicated chromosomes are pulled apart by...
Kinetochores are enormous multiprotein complexes built on centromeric chromatin that link chromosome...
Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from t...
SummaryThe kinetochore is the macromolecular protein complex that directs chromosome segregation in ...
Kinetochores are highly specialized macromolecular machines built on top of centromeric chromatin to...
AbstractAccurate chromosome segregation is essential to ensure genomic stability because the aneuplo...
The kinetochore is a multi-protein complex that connects the chromosome with microtubule and pulls t...
Kinetochore attachment to spindle microtubule plus-ends is necessary for accurate chromosome segrega...
The fundamental property of living systems is their ability to consume resources from their environm...
The kinetochore is the protein machine built at the centromere that integrates mechanical force and ...