Endothelin stimulates both cAMP formation and phosphatidylinositol hydrolysis in cultured embryonic bovine tracheal cells
- Oda, Kyoko
- Fujitani, Yasushi
- Watakabe, Tadashi
- Inui, Takashi
- Okada, Toshikazu
- Urade, Yoshihiro
- Okuda-Ashitaka, Emiko
- Ito, Seiji
Publication date
March 1992
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793Abstract
AbstractEmbryonic bovine tracheal (EBTr) cells were found to possess receptors for endothelin (ET) of ET-1-selective (ETA)subtype with a Kd for ET-1 of 114 pM and a Bmax of 12.9 fmol/105 cells. Stimulation of EBTr cells with 100 pM to 100 nM ET-1 increased the contents of both inositol phosphates and cAMP in a concentration-dependent manner, indicating that the receptors are coupled to both phosphatidylinositol hydrolysis and cAMP formation in EBTr cells
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