AbstractWhile normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer. In a three-dimensional model of morphogenesis, we show that down-regulation of the matrix-associated tumor suppressor protein CCN6 (WNT1-inducible-signaling pathway protein 3) disrupts breast epithelial cell polarity and organization into acini through up-regulation of the type III transforming growth factor-β receptor (TβRIII or betaglycan). Down-regulation of CCN6 in benign breast cells led to loss of tissue polarity and resulted in cellular disorganization with loss of α6 integrin-rich basement membrane and the basolateral polarity protein E-cadherin. Silencing of TβRIII with shRNA and siRNA ...
14-3-3ζ is a ubiquitously expressed family member of proteins that have been implicated to have onco...
The mammary gland is a unique and specialized epidermal organ; mammary organogenesis begins in the e...
Members of the epidermal growth factor (EGF) receptor family are known to be specifically involved i...
AbstractWhile normal cells in the human breast are organized into acinar structures, disruption of t...
Abstract Introduction CCN6/WISP3 belongs to the CCN (...
During progression of breast cancer, CCN6 protein exerts tumor inhibitory functions. CCN6 is a secre...
Breast cancer is one of the deadliest malignancies worldwide and also in the United States. Patients...
Reestablishing tissue organization of breast cancer cells into acini was previously shown to overrid...
The CCN family of matricellular proteins is essential for cell communication and mediation of epithe...
The integrin α6β4 (referred to as β4) is expressed in epithelial cells where it functions as a lamin...
AbstractDespite evidence demonstrating the role of β1-integrin in the regulation of cancer cell prol...
We previously established a rapid three-dimensional assay for discrimination of normal and malignant...
[[abstract]]Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade loca...
Our previous data illustrated that activation of the canonical Wnt signaling pathway was enriched in...
AbstractBone morphogenetic proteins (BMPs) are members of the TGF-β superfamily that are over-expres...
14-3-3ζ is a ubiquitously expressed family member of proteins that have been implicated to have onco...
The mammary gland is a unique and specialized epidermal organ; mammary organogenesis begins in the e...
Members of the epidermal growth factor (EGF) receptor family are known to be specifically involved i...
AbstractWhile normal cells in the human breast are organized into acinar structures, disruption of t...
Abstract Introduction CCN6/WISP3 belongs to the CCN (...
During progression of breast cancer, CCN6 protein exerts tumor inhibitory functions. CCN6 is a secre...
Breast cancer is one of the deadliest malignancies worldwide and also in the United States. Patients...
Reestablishing tissue organization of breast cancer cells into acini was previously shown to overrid...
The CCN family of matricellular proteins is essential for cell communication and mediation of epithe...
The integrin α6β4 (referred to as β4) is expressed in epithelial cells where it functions as a lamin...
AbstractDespite evidence demonstrating the role of β1-integrin in the regulation of cancer cell prol...
We previously established a rapid three-dimensional assay for discrimination of normal and malignant...
[[abstract]]Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade loca...
Our previous data illustrated that activation of the canonical Wnt signaling pathway was enriched in...
AbstractBone morphogenetic proteins (BMPs) are members of the TGF-β superfamily that are over-expres...
14-3-3ζ is a ubiquitously expressed family member of proteins that have been implicated to have onco...
The mammary gland is a unique and specialized epidermal organ; mammary organogenesis begins in the e...
Members of the epidermal growth factor (EGF) receptor family are known to be specifically involved i...