AbstractRecently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms
The goal of this research is to develop new allosteric thymidylate synthase (TS) inhibitors ...
The discovery and development of novel small molecules as anti-cancer agents plays an integral role ...
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins ha...
AbstractRecently, a class of small molecules that thermally stabilize the tumor suppressor p53 was s...
Given the immense significance of p53 restoration for anti-cancer therapy and that p53-activating mo...
SummaryEnzymes that regulate their activity by modulating an equilibrium of alternate, nonadditive, ...
Loss of function of p53, either through mutations in the gene or through mutations to other members ...
Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation occurs via ligands for a...
SummaryThe destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the...
Discovery of new pharmacologically active small molecules is an important and rapidly expanding area...
SummaryThe p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can...
The Author(s) 2014. This article is published with open access at Springerlink.com Abstract Loss of ...
Herein we examine the determinants of the allosteric inhibition of the mitochondrial chaperone TRAP1...
Recent advances in structural biology and computational techniques have revealed allosteric mechanis...
The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protei...
The goal of this research is to develop new allosteric thymidylate synthase (TS) inhibitors ...
The discovery and development of novel small molecules as anti-cancer agents plays an integral role ...
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins ha...
AbstractRecently, a class of small molecules that thermally stabilize the tumor suppressor p53 was s...
Given the immense significance of p53 restoration for anti-cancer therapy and that p53-activating mo...
SummaryEnzymes that regulate their activity by modulating an equilibrium of alternate, nonadditive, ...
Loss of function of p53, either through mutations in the gene or through mutations to other members ...
Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation occurs via ligands for a...
SummaryThe destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the...
Discovery of new pharmacologically active small molecules is an important and rapidly expanding area...
SummaryThe p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can...
The Author(s) 2014. This article is published with open access at Springerlink.com Abstract Loss of ...
Herein we examine the determinants of the allosteric inhibition of the mitochondrial chaperone TRAP1...
Recent advances in structural biology and computational techniques have revealed allosteric mechanis...
The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protei...
The goal of this research is to develop new allosteric thymidylate synthase (TS) inhibitors ...
The discovery and development of novel small molecules as anti-cancer agents plays an integral role ...
Understanding molecular mechanisms underlying the complexity of allosteric regulation in proteins ha...
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