Existing models of Huntington’s disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunction
Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF fun...
Huntington disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the hunti...
Boosting trophic support to striatal neurons by increasing levels of brain-derived neurotrophic fact...
Existing models of Huntington’s disease posit that deficits in BDNF delivery to the striatum contrib...
SummaryHuntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitati...
Many pathways have been proposed as contributing to Huntington's disease (HD) pathogenesis, but gene...
Loss of huntingtin-mediated BDNF gene transcription has been shown to occur in HD and thus contribut...
Introduction: BDNF is essential for the survival of striatum and is dramatically reduced in Hunting...
Loss of huntingtin-mediated BDNF gene transcription has been shown to occur in HD and thus contribut...
Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been...
Huntington disease (HD) is an inherited neurodegenerative disorder caused by expansion of the CAG re...
Neurotrophic factors are essential contributors to the survival of peripheral and central nervous sy...
Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However, the mecha...
The physiology of brain-derived neurotrophic factor signaling in enkephalinergic striatopallidal neu...
Background Brain-Derived Neurotrophic Factor (BDNF) is the main candidate for neuroprotective therap...
Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF fun...
Huntington disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the hunti...
Boosting trophic support to striatal neurons by increasing levels of brain-derived neurotrophic fact...
Existing models of Huntington’s disease posit that deficits in BDNF delivery to the striatum contrib...
SummaryHuntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitati...
Many pathways have been proposed as contributing to Huntington's disease (HD) pathogenesis, but gene...
Loss of huntingtin-mediated BDNF gene transcription has been shown to occur in HD and thus contribut...
Introduction: BDNF is essential for the survival of striatum and is dramatically reduced in Hunting...
Loss of huntingtin-mediated BDNF gene transcription has been shown to occur in HD and thus contribut...
Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been...
Huntington disease (HD) is an inherited neurodegenerative disorder caused by expansion of the CAG re...
Neurotrophic factors are essential contributors to the survival of peripheral and central nervous sy...
Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However, the mecha...
The physiology of brain-derived neurotrophic factor signaling in enkephalinergic striatopallidal neu...
Background Brain-Derived Neurotrophic Factor (BDNF) is the main candidate for neuroprotective therap...
Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF fun...
Huntington disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the hunti...
Boosting trophic support to striatal neurons by increasing levels of brain-derived neurotrophic fact...
DOI
Add to ORKG