Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabolic syndrome. A new study in this issue of Cell Metabolism (Sun et al., 2007) shows that SIRT1, a mammalian sirtuin homolog and histone deacetylase, can ameliorate insulin resistance by silencing expression of protein tyrosine phosphatase 1B, a major negative regulator of insulin action
Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy meta...
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment...
AbstractSirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide-dependent histone deacetylase, is a...
Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabo...
SummaryInsulin resistance is often characterized as the most critical factor contributing to the dev...
Dysregulation of metabolic pathways leads to type 2 diabetes, characteristic of high glucose concent...
The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase ...
Objective: Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metab...
AbstractSIRT2 is primarily a cytoplasmic protein deacetylase and is abundantly expressed in metaboli...
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel ...
SIRT1, a NAD+-dependent protein deacetylase that regulates transcription factors involved in key cel...
Insulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) ...
SummaryIn yeast, worms, and flies, an extra copy of the gene encoding the Sirtuin Sir2 increases met...
Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism t...
OBJECTIVE: Sirtuins (SIRTs) are NAD(+)-dependent deacetylases that regulate metabolism and life span...
Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy meta...
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment...
AbstractSirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide-dependent histone deacetylase, is a...
Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabo...
SummaryInsulin resistance is often characterized as the most critical factor contributing to the dev...
Dysregulation of metabolic pathways leads to type 2 diabetes, characteristic of high glucose concent...
The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase ...
Objective: Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metab...
AbstractSIRT2 is primarily a cytoplasmic protein deacetylase and is abundantly expressed in metaboli...
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel ...
SIRT1, a NAD+-dependent protein deacetylase that regulates transcription factors involved in key cel...
Insulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) ...
SummaryIn yeast, worms, and flies, an extra copy of the gene encoding the Sirtuin Sir2 increases met...
Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism t...
OBJECTIVE: Sirtuins (SIRTs) are NAD(+)-dependent deacetylases that regulate metabolism and life span...
Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy meta...
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment...
AbstractSirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide-dependent histone deacetylase, is a...