The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression remain largely unresolved. Findings by Ghavidel et al. (2007) reported in this issue suggest that tRNA trafficking and the transcription factor Gcn4 are key intermediates in the process by which yeast cells detect DNA damage and delay cell-cycle progression at the G1 to S phase transition
Genome instability, defined as the occurrence and amplification of mutations and chromosomal rearran...
The DNA damage checkpoint is a surveillance mechanism evolved to preserve genome integrity in respon...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression remain large...
SummaryIn response to genotoxic stress, cells evoke a plethora of physiological responses collective...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
S-phase and DNA damage promote increased ribonucleotide reductase (RNR) activity. Translation of RNR...
Cell cycle events are ordered correctly; mitosis follows DNA replication. To ensure correct order, c...
Transcription–replication (T–R) conflicts are profound threats to genome integrity. However, whilst ...
AbstractWe demonstrate that in S. cerevisiae the rate of ongoing S phase is slowed when the DNA is s...
Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinat...
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral i...
In response to genotoxic agents and cell cycle blocks all eukaryotic cells activate a set of surveil...
Genome instability, defined as the occurrence and amplification of mutations and chromosomal rearran...
The DNA damage checkpoint is a surveillance mechanism evolved to preserve genome integrity in respon...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression remain large...
SummaryIn response to genotoxic stress, cells evoke a plethora of physiological responses collective...
SummaryTrex1 is the major 3′ DNA exonuclease in mammalian cells, and mutations in the human TREX1 ge...
Trex1, a major 3′ DNA exonuclease in mammalian cells, has been thought to act primarily in DNA repli...
SummaryDetection of nucleic acids and induction of type I interferons (IFNs) are principal elements ...
S-phase and DNA damage promote increased ribonucleotide reductase (RNR) activity. Translation of RNR...
Cell cycle events are ordered correctly; mitosis follows DNA replication. To ensure correct order, c...
Transcription–replication (T–R) conflicts are profound threats to genome integrity. However, whilst ...
AbstractWe demonstrate that in S. cerevisiae the rate of ongoing S phase is slowed when the DNA is s...
Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinat...
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral i...
In response to genotoxic agents and cell cycle blocks all eukaryotic cells activate a set of surveil...
Genome instability, defined as the occurrence and amplification of mutations and chromosomal rearran...
The DNA damage checkpoint is a surveillance mechanism evolved to preserve genome integrity in respon...
In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune resp...
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