AbstractWe obtain a tableau definition of the skew Schubert polynomials named by Lascoux, which are defined as flagged double skew Schur functions. These polynomials are in fact Schubert polynomials in two sets of variables indexed by 321-avoiding permutations. From the divided difference definition of the skew Schubert polynomials, we construct a lattice path interpretation based on the Chen–Li–Louck pairing lemma. The lattice path explanation immediately leads to the determinantal definition and the tableau definition of the skew Schubert polynomials. For the case of a single variable set, the skew Schubert polynomials reduce to flagged skew Schur functions as studied by Wachs and by Billey, Jockusch, and Stanley. We also present a lattic...