Antibody affinity maturation involves selective survival of high affinity B cells and is thought to require the germinal center (GC) microenvironment. In this issue of Immunity, Di Niro et al. (2015) challenge this view, showing that low affinity B cells initiate Salmonella responses and affinity mature outside of GCs
The T-dependent humoral immune response is critical for generation of durable high-affinity antibody...
B cells produce high-affinity immunoglobulins (Igs), or antibodies, to eliminate foreign pathogens. ...
In response to antigenic challenge, the production of high-affinity, antibody secreting plasma cells...
Antibody affinity maturation involves selective survival of high affinity B cells and is thought to ...
SummaryThe B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites...
Protective antibody responses to vaccination or infection depend on affinity maturation, a process b...
Germinal centers (GCs) form in lymph nodes after immunization or infection to facilitate antibody af...
A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum ...
Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic ...
The maturation of antibody affinity during the immune response, discovered as a serological phenomen...
The adaptive immune system has the extraordinary ability to develop bespoke antibodies against almos...
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites, witho...
Germinal centres (GCs) are the sites where V-gene hypermutation and B cell selection are taking plac...
Germinal centers (GCs) are important sites of antibody affinity maturation. In the classical model, ...
The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora...
The T-dependent humoral immune response is critical for generation of durable high-affinity antibody...
B cells produce high-affinity immunoglobulins (Igs), or antibodies, to eliminate foreign pathogens. ...
In response to antigenic challenge, the production of high-affinity, antibody secreting plasma cells...
Antibody affinity maturation involves selective survival of high affinity B cells and is thought to ...
SummaryThe B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites...
Protective antibody responses to vaccination or infection depend on affinity maturation, a process b...
Germinal centers (GCs) form in lymph nodes after immunization or infection to facilitate antibody af...
A hallmark of T cell-dependent immune responses is the progressive increase in the ability of serum ...
Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic ...
The maturation of antibody affinity during the immune response, discovered as a serological phenomen...
The adaptive immune system has the extraordinary ability to develop bespoke antibodies against almos...
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular sites, witho...
Germinal centres (GCs) are the sites where V-gene hypermutation and B cell selection are taking plac...
Germinal centers (GCs) are important sites of antibody affinity maturation. In the classical model, ...
The mechanisms of B cell selection in lymphoid tissues are poorly understood. In this issue, Victora...
The T-dependent humoral immune response is critical for generation of durable high-affinity antibody...
B cells produce high-affinity immunoglobulins (Igs), or antibodies, to eliminate foreign pathogens. ...
In response to antigenic challenge, the production of high-affinity, antibody secreting plasma cells...
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